Alprazolam - oral

Patient Medicine Information
Why do I need this medicine?
Alprazolam is used to treat anxiety. It is used for short-term relief of moderate or severe anxiety, or anxiety associated with depression.

This medicine may also be used to treat panic disorder with or without fear of places and situations that might cause panic, helplessness, or embarrassment.
How do I take this medicine?
Take Alprazolam exactly as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor.

This medicine may be taken with or without food. You may take it immediately after meals to reduce the sleepiness or drowsiness that it may cause. Try to take it at the same time each day.

Alprazolam is available as a tablet (in conventional, orally disintegrating or extended-release form), or as an oral concentrated solution.

If you are taking the extended-release type of tablet (usually labelled as “ER”), swallow it whole. Do not divide, chew or crush the tablet.

If you are taking the orodispersible tablet:
  1. Remove it from the foil only just before you take it. Do not leave the orodispersible tablet exposed to air. Do not push the orodispersible tablet through the foil as it is fragile and easily broken.
  2. Remove the orodispersible tablet with dry hands by peeling the backing off the foil and tipping the tablet onto your dry hands.
  3. Place the orodispersible tablet directly on your tongue as soon as it is taken out of the foil. The orodispersible tablet will immediately start to melt on the tongue. It can then be swallowed with or without water.
Do not cut, break or crush the orodispersible tablets.

If you are taking the oral concentrated solution, shake the bottle well before taking it to ensure that the liquid is evenly mixed. Use the calibrated dropper provided to measure out your dose. The oral concentrated solution may be mixed with more than 30 mL of juice, other liquids, or semi-solid food (e.g. applesauce, pudding). The mixture should be taken immediately.

The dose of this medicine will be decided by your doctor. Your doctor will advise you on the treatment timeframe depending on your condition and response to the medication.

Do not take this medicine for a longer period than instructed by your doctor. Inform your doctor if this medicine does not seem to help you.

Do not stop taking Alprazolam suddenly as it may worsen your condition. Your doctor will gradually reduce the dose before stopping it completely. Follow your doctor's instructions carefully.
What should I do if I have forgotten to take this medicine?
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your normal dosing schedule.

DO NOT double a dose under any circumstances.

If you often forget to take your medicine, let your doctor and pharmacist know.
When should I not use this medicine?
Alert your doctor if you have the following conditions:
  • myasthenia gravis (a muscle weakness disorder)
  • sleep apnoea (sleep disorder that causes interrupted breathing during sleep)
  • narrow-angle glaucoma (increased pressure in the eyes)
  • severe lung disease
  • severe liver disease
as this medicine may not be suitable for you.

Do not take Alprazolam with medicines used to treat fungal infections such as ketoconazole and itraconazole.
What should I take note of while taking this medicine?
Inform your doctor if you have the following conditions:
  • other mood disorders e.g. depression, suicidal thoughts, personality disorders
  • epilepsy (fits or seizures)
  • lung disease
  • condition which increases risks of falls
  • history of drug abuse or alcoholism
  • cigarette smoking
  • kidney disease
  • mild to moderate liver disease
Let your doctor know if you are pregnant or breastfeeding.

Be sure to check with your doctor or pharmacist before giving Alprazolam to an elderly, or to those who are obese or debilitated (a person who is physically or mentally weak usually due to illness or old age) as they may be more sensitive to the side effects of this medicine.

This medicine is not intended for long-term use or used as main treatment for psychotic illness.

Keep your appointments with your doctor. Your doctor needs to monitor your condition and check your response to the medication regularly.
  • Your doctor may need to monitor your heart and lung status while you are being treated with this medicine.
  • Monitoring for signs of depression and drug abuse, dependence, or tolerance may also be needed.
What side effects could I experience?
Alprazolam may cause drowsiness, sleepiness, or impaired concentration. If affected, do not drive or take part in any activity in which you need to be alert.

Other side effects include any of the following: headache, dizziness, blurred vision, stuffy nose, nausea, dry mouth, constipation, loss of appetite, increased or decreased in weight, tiredness, slurred speech, and difficulty sleeping.

This medicine may also cause abnormal activities during sleep (e.g. driving, cooking, eating, walking and making phone calls while you are still asleep). Alert your doctor quickly if this happens.

Some side effects may need immediate medical help. Alert your doctor quickly if you experience any of the following:
  • rashes, breathlessness, swollen eyes, face or throat
  • memory loss or problems
  • yellowing of the skin or eyes
  • having thoughts of self-harm
  • unusual changes in mood or behaviour (being too depressed, agitated, violent, aggressive, or having compulsive and impulsive behaviour)
  • hallucinations (seeing, hearing or feeling things that are not existent)
  • muscle pain, tremors, restlessness, sensitivity to light, noise or touch, fits or seizures
Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Can I take this with other medicines?
Do not take Alprazolam with medicines used to treat fungal infections such as ketoconazole and itraconazole.

Inform your doctor and pharmacist if you are taking any of these medicines:
  • medicines to treat depression e.g. nefazodone, fluvoxamine, fluoxetine, sertraline, paroxetine
  • medicines for mood disorders e.g. lithium
  • medicines for epilepsy (fits or seizures) e.g. carbamazepine
  • strong painkillers e.g. propoxyphene
  • certain antibiotics e.g. erythromycin, clarithromycin, troleandomycin
  • digoxin (medicine for heart disease)
  • diltiazem (medicine for high blood pressure)
  • ritonavir (medicine for HIV infection)
  • cimetidine (gastric medicine)
  • birth control pills
This list does not include all medicines that may interact with Alprazolam.

Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements and medicines that you buy without a prescription.
What special dietary instructions should I follow?
Avoid alcohol and St. John’s wort.

Avoid excessive consumption of grapefruit or grapefruit juice (more than 1 litre a day).
How should I store this medicine?
Store in a cool, dry place away from the reach of children. Protect from moisture.

The oral concentrated solution can be stored at room temperature between 20-25°C. Throw away any unused portion after 90 days.

Medicines must not be used past the expiry date.
This information is independently developed by MIMS based on alprazolam - oral and is provided for your reference only. It is not a replacement for and should only be used in conjunction with full consultation with a licensed healthcare professional, the information provided by your pharmacist and/or the manufacturer of the medication. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, we shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 MIMS. All rights reserved. Powered by
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