Alvotinib Indications/Uses





Zuellig Pharma
Full Prescribing Info
Alvotinib is indicated for the treatment of: Paediatric patients with newly diagnosed Philadelphia chromosome (bcr-abl) positive (Ph+) chronic myeloid leukaemia (CML) for whom bone marrow transplantation is not considered as the first line of treatment; paediatric patients with Ph+ CML in chronic phase after failure of interferon-alpha therapy, or in accelerated phase; adult and paediatric patients with Ph+ CML in blast crisis in the accelerated phase or in the chronic phase of the disease after failure of interferon alfa therapy.
Treatment of adult with Kit (CD117) positive unresectable and/or metastatic malignant gastrointestinal stromal tumours (GIST).
Adjuvant treatment of adult patient following resection of GIST with a tumor size ≥ 3 cm.
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