Alzime

Alzime

donepezil

Manufacturer:

Berlin Pharm

Distributor:

Berlin Pharm

Marketer:

Berlin Pharm
Concise Prescribing Info
Contents
Donepezil HCl
Indications/Uses
Mild to moderate dementia of Alzheimer's type as well as severe dementia. Vascular dementia. Dementia w/ Lewy bodies (DLB).
Dosage/Direction for Use
Mild to moderate Alzheimer's disease, vascular dementia, dementia w/ Lewy bodies 5 or 10 mg once daily in the evening. Severe Alzheimer's disease 10 mg once daily in the evening.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity to donepezil HCl or piperidine derivatives.
Special Precautions
May cause bradycardia &/or heart block w/ or w/o history of cardiac disease, syncopal episodes; dose-related diarrhea, nausea &/or vomiting; anorexia &/or wt loss. Sick sinus syndrome or other supraventricular cardiac conduction abnormalities, COPD, or asthma; history of seizure disorder; risk of ulcer disease (eg, previous history or NSAID use), or in patients w/ bladder outlet obstructions; dose-related diarrhea, nausea, &/or vomiting, anorexia &/or wt loss. Concomitant use w/ depolarizing neuromuscular blockers (eg, succinylcholine). May exaggerate succinyl-choline type muscle relaxation during anaesth. Closely monitor for symptoms of active or occult GI bleeding especially those w/ history of ulcer disease or receiving concurrent NSAIDs. Hepatic function impairment. Clastogenic effects. Pregnancy & lactation.
Adverse Reactions
Insomnia; nausea, diarrhea; accident, infection.
Drug Interactions
Potential to interfere w/ activity of anticholinergics eg, atropine. Synergistic effect w/ succinylcholine, other neuromuscular-blocking agents, or cholinergic agonists (eg, bethanechol). Increase gastric acid secretions w/ NSAIDs eg, ibuprofen, naproxen. Increased AUC0-24 & Cmax w/ ketoconazole. Increased rate of elimination w/ CYP3A4 & CYP2D6 inducers eg, carbamazepine, dexamethasone, phenobarb, phenytoin, rifampin.
ATC Classification
N06DA02 - donepezil ; Belongs to the class of anticholinesterases. Used in the management of dementia.
Presentation/Packing
Form
Alzime FC tab 10 mg
Packing/Price
3 × 10's
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