Amarax 2

Glimepiride

Management of type 2 DM (NIDDM) as an adjunct to diet & exercise to lower blood glucose. In combination w/ metformin or insulin in patients whose hyperglycemia cannot be controlled by diet & exercise in conjunction w/ a single oral hypoglycemic agent.

Initially 1-2 mg once daily. Maintenance dose: 1-4 mg once daily, may be increased in 2-mg increments at 1-2 wk intervals after a dose of 2 mg once daily. Max dose: 8 mg once daily. In combination w/ insulin Initially 8 mg once daily.

Should be taken with food: Take immediately before or during breakfast, or the 1st main meal of the day. Do not skip meals.

Hypersensitivity to glimepiride or sulfonamides. Diabetic ketoacidosis.

Severe hypoglycemia. Renal & hepatic impairment. Malnourished patients. Regularly monitor glucose levels in blood & urine. Patients w/ G6PD & rare hereditary problems of galactose intolerance. Pregnancy & lactation. Elderly. Childn. 

Dizziness, headache, hypoglycemia, nausea & weakness.

Potentiation of blood sugar-lowering effect by insulin, oral antidiabetics, ACE inhibitors, allopurinol, anabolic steroids & male sex hormones, chloramphenicol, coumarin derivatives, cyclophosphamide, disopyramide, fenfluramine, fenyramidol, fibrates, fluoxetine, guanethidine, ifosfamide, MAOIs, miconazole, para-aminosalicylic acid, quinolones, salicylates, sulfinpyrazone, sulfonamides, tetracyclines, tritoqualine, trofosfamide. Raised blood sugar levels w/ acetazolamide, barbiturates, corticosteroids, diazoxide, diuretics, epinephrine & other sympathomimetic agents, glucagons, laxatives (after protracted use), nicotinic acid (in high dose), estrogens & progestrogens, phenothiazines, phenytoin, rifampicin, thyroid hormones.

Antidiabetic Agents

A10BB12 - glimepiride ; Belongs to the class of sulfonylureas. Used in the treatment of diabetes.

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