Amaryl

Amaryl

glimepiride

Manufacturer:

Sanofi-Aventis

Distributor:

DKSH
Concise Prescribing Info
Contents
Glimepiride
Dosage/Direction for Use
Initially 1 mg daily. Usual maintenance dose: 1-4 mg daily. Max daily dose: 6 mg (in exceptional cases, 8 mg).
Administration
Should be taken with food: Take immediately before the 1st main meal of the day. Do not skip meals. Swallow whole, do not chew.
Contraindications
Type 1 IDDM, diabetic ketoacidosis; diabetic precoma or coma; hypersensitivity to other sulfonylureas or sulfonamides; serious renal or hepatic dysfunction; dialysis patients. Pregnancy & lactation.
Special Precautions
Regular monitoring of glucose levels in blood & urine. Milder or absent symptoms of hypoglycemia eg, in patients w/ autonomic neuropathy or taking β-blockers, clonidine, reserpine, guanethidine or other sympatholytic drugs. Temporary changeover to insulin. In exceptional stress situations (eg, trauma, surgery, infections w/ fever).
Adverse Reactions
Hypoglycemia; adrenergic counter-regulation; temporary visual impairment; GI symptoms. Rarely, thrombopenia, haemolytic anaemia, erythrocytopenia, leucopenia, agranulocytosis.
Drug Interactions
Potentiation of the blood sugar-lowering effect by insulin & other (oral) antidiabetics, ACE inhibitors, allopurinol, anabolic steroids & male sex hormones, azapropazone, chloramphenicol, coumarin derivatives, fibrates, fluoxetine, ifosfamide, MAOIs, miconazole, oxyphenbutazone, pentoxifylline, probenecid, quinolones, salicylates, sulfonamides, tetracyclines. Weakening of the blood sugar-lowering effect by acetazolamide, barbiturates, corticosteroids, diazoxide, diuretics, epinephrine & other sympathomimetic agents, glucagon, laxatives, (after protracted use), nicotinic acid (in high doses), oestrogens & progestogens, phenothiazines, phenytoin, rifampicin, thyroid hormones.
MIMS Class
Antidiabetic Agents
ATC Classification
A10BB12 - glimepiride ; Belongs to the class of sulfonylureas. Used in the treatment of diabetes.
Presentation/Packing
Form
Amaryl tab 1 mg
Packing/Price
120's
Form
Amaryl tab 2 mg
Packing/Price
120's
Form
Amaryl tab 3 mg
Packing/Price
120's
Form
Amaryl tab 4 mg
Packing/Price
30's
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