Concise Prescribing Info
Amlodipine besylate
Alone or in combination w/ other classes of antihypertensive drugs for the treatment of HTN; management of Prinzmetal's variant angina & chronic stable angina pectoris. Patient's w/ recently documented CAD by angiography (w/o heart failure or an ejection fraction <40%).
Dosage/Direction for Use
HTN Adult Initially 2.5-5 mg once daily. Max: 10 mg once daily. Dose may be increased gradually at 7-14 days interval. Maintenance dose: 5-10 mg once daily. Childn 6-17 yr 2.5-5 mg once daily. Elderly Initially 2.5 mg once daily. Hepatic impairment Initially 2.5 mg daily. Max dose: 10 mg once daily. Prinzmetal's variant angina or chronic stable angina Adult 5-10 mg once daily. Maintenance dose: 10 mg daily. Elderly 5 mg once daily. Hepatic impairment 5 mg. Maintenance dose: 10 mg daily. Angiographically documented CAD Adult 5-10 mg once daily.
May be taken with or without food.
Hypersensitivity to amlodipine & drugs under dihydropyridine.
Special Precautions
Increased angina &/or MI may occur. Impaired hepatic function. Possible occurrence of hypotension in patients w/ severe aortic stenosis &/or hypertrophic cardiomyopathy. Pregnancy & lactation. Childn <6 yr. Elderly.
Adverse Reactions
Headache & edema. Dizziness, flushing & palpitation; fatigue, nausea, abdominal pain, & somnolence.
Drug Interactions
Increased levels/effects w/ α1-blockers, antifungal agents (azole derivatives), Ca channel blockers (nondihydropyridine), cyclosporine, strong & moderate CYP3A4 inhibitor, dasatinib, diazoxide, fluconazole, grapefruit juice, herbs (hypotensive properties), macrolide antibiotics, Mg salts, MAOIs, pentoxifylline, phosphodiesterase 5 inhibitors, prostacyclin analogues, PIs, quinupristin. Increase the levels/effects of amifostine, antihypertensives, CYP1A2 substrates, hypotensive agents, Mg salts, neuromuscular-blocking agents (non-depolarizing), nitroprusside, phenytoin, rituximab, tacrolimus. Decreased levels/effects w/ barbiturates, Ca salts, carbamazepine, strong CYP3A4 inducers, deferasirox, herbs (CYP3A4 inducers & hypertensive properties), methylphenidate, nafcillin, rifamycin derivatives, yohimbine, St. John's wort. Decrease levels/effects of clopidogrel, quinidine. Concurrent use w/ lithium potentially may result in the form of nausea, vomiting, diarrhea, ataxia, tremors, &/or tinnitus. May worsen HTN w/ ephedra, yohimbe, ginseng. Increased hypertensive effects w/ garlic.
MIMS Class
ATC Classification
C08CA01 - amlodipine ; Belongs to the class of dihydropyridine derivative selective calcium-channel blockers with mainly vascular effects. Used in the treatment of cardiovascular diseases.
Ambes-5 tab 5 mg
10 × 10's
Ambes-10 tab 10 mg
10 × 10's
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