The levels/ effects of amlodipine may be increased by α1-blockers, antifungal agents (azole derivatives), calcium channel blockers (nondihydropyridine), cyclosporine, moderate inhibitors of CYP3A4, strong inhibitors of CYP3A4, desatinib, diazoxide, fluconazole, grapefruit juice, herbs (hypotensive properties), macrolide antibiotics, magnesium salts, monoamine oxidase inhibitors, pentoxifylline, phosphodiesterase 5 inhibitors, prostacyclin analogues, protease inhibitors, quinupristin.
Amlodipine may increase the levels/effects of amifostine, antihypertensives, CYP1A2 substrates, hypotensive agents, magnesium salts, neuromuscular-blocking agents (non-depolarizing), nitroprusside, phenytoin, rituximab, tacrolimus.
The levels/effects of amlodipine may be decreases by barbiturates, calcium salts, carbamazepine, strong inducers of CYP3A4, defasirox, herbs (CYP3A4 inducers), herbs (hypertensive properties), methylphenidate, nafcillin, rifamycin derivatives, yohimbine.
Amlodipine may decrease the levels/effects of clopidogrel, quinidine.
Concurrent use with lithium potentially may result in the form of nausea, vomiting, diarrhea, ataxia, tremors, and/or tinnitus.
St. John's wort may decrease amlodipine levels.
Avoid using ephedra, yohimbe and ginseng. They may worsen hypertension.
Avoid using garlic. It may have increased antihypertensive effects.