Hypertension: Amlodipine is used alone or in combination with other classes of antihypertensive drugs for the treatment of hypertension. Data from clinical outcome trials indicate that lowering the blood pressure with any of several classes of drugs, including thiazides, β-blockers, calcium-channel blockers, ACE inhibitors, or angiotensin II receptor antagonists will reduce the complications of hypertension.
Coronary Artery Disease: Angina: Amlodipine is used alone or in combination with other antianginal agents for the management of Prinzmetal's variant angina and chronic stable angina pectoris.
Angiographically Documented Coronary Artery Disease (CAD): Amlodipine is used in patients with recently documented coronary artery disease by angiography (without heart failure or an ejection fraction less than 40%) to reduce the risk of coronary revascularization procedure and hospitalization due to angina.
Notes: Data from a multicentre randomized controlled trial (ASCOT-BPLA) indicated that amlodipine-based regimen (amlodipine adding perindopril) reduced the risk of non-fatal myocardial infarction, fatal coronary heart disease, and stroke.