Amvas/Amvas 10

Amvas/Amvas 10





Prosp Pharma
Concise Prescribing Info
Amlodipine besylate
Amvas HTN & myocardial ischemia due to fixed obstructions. Amvas 10 Alone or in combination w/ other antihypertensive or other antianginal drugs for the treatment of HTN, chronic stable angina & confirmed or suspected vasospastic angina (Prinzmetal's or variant angina).
Dosage/Direction for Use
Amvas Initially 5 mg once daily. Max: 10 mg. Amvas 10 HTN Initially 5 mg once daily. Max dose: 10 mg once daily. Elderly or patients w/ hepatic insufficiency Initially 2.5 mg once daily. Titration should proceed over 7-14 days. Chronic stable or vasospastic angina 5-10 mg once daily.
May be taken with or without food.
Special Precautions
Amvas Heart failure, impaired liver function. Amvas 10 CHF, hepatic function impairment. Elderly. Pregnancy & lactation (discontinue).
Adverse Reactions
Amvas Headache, edema, nausea, flushing, dizziness. Amvas 10 Peripheral edema, abdominal pain, flushing, headache, somnolence. Dizziness, palpitations, fatigue, rash, pruritus, male sexual dysfunction, nausea, dyspepsia, muscle cramps, weakness, dyspnea, pulmonary edema. Angina, bradycardia, hypotension, jaundice & orthostatic hypotension.
Drug Interactions
Amvas 10 Produce additive hypotension w/ anesth & hydrocarbon inhalation. Ca channel blockers. Reduced antihypertensive effects w/ NSAIDs (indomethacin) & sympathomimetics. β-adrenergic blockers. Increased BP w/ estrogens. Antihypertensive effects may be potentiated w/ hypotension-producing drugs. Neurotoxicity w/ lithium & changes of unbound serum conc of highly protein bound drugs.
ATC Classification
C08CA01 - amlodipine ; Belongs to the class of dihydropyridine derivative selective calcium-channel blockers with mainly vascular effects. Used in the treatment of cardiovascular diseases.
Amvas 10 tab 10 mg
100 × 10's
Amvas tab 5 mg
10 × 10's
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