Use in Patients with Congestive Heart Failure: Amlodipine should be used with caution in patient with congestive heart failure because of the slight risk of negative inotropic effect.
Use in Patients with Hepatic Function Impairment: Clearance of amlodipine may be reduced since it undergoes extensive hepatic metabolism, elimination half-life may be prolonged. The drug should therefore be administered with caution in these patients.
Use in Elderly: The half-life of amlodipine may be increased in the elderly. These patients may be more sensitive to the hypotensive effects of amlodipine and may require a lower initial dose.