Arava

Arava

leflunomide

Manufacturer:

Sanofi-Aventis

Distributor:

DKSH
Concise Prescribing Info
Contents
Leflunomide
Indications/Uses
Reduce signs, symptoms & structural damage in active RA. Improve joint symptoms & skin lesions in active PSA. Active psoriatic arthritis.
Dosage/Direction for Use
Adult Initially, loading dose: 100 mg daily for 3 days. Maintenance: 20 mg daily.
Administration
May be taken with or without food.
Contraindications
Women who are or may become pregnant, lactation. Severe immunodeficiency states, significantly impaired bone marrow function or significant anemia, leukopenia, neutropenia or thrombocytopenia due to causes other than RA, serious infections, moderate to severe renal insufficiency, impairment of liver function, severe hypoproteinemia.
Special Precautions
Preexisting anemia, leucopenia, thrombocytopenia, impaired bone marrow function or those at risk of bone marrow suppression, renal insufficiency, ped & geriatric use.
Adverse Reactions
GI disturbances, elevation of liver parameters, leukopenia. Headache, dizziness, asthenia. Increase in BP, wt loss, increased hair loss.
Drug Interactions
Cholestyramine, charcoal, tolbutamide, rifampicin, hepatotoxic drugs.
MIMS Class
Disease-Modifying Anti-Rheumatic Drugs (DMARDs)
ATC Classification
L04AA13 - leflunomide ; Belongs to the class of selective immunosuppressive agents. Used to induce immunosuppression.
Presentation/Packing
Form
Arava tab 20 mg
Packing/Price
30's
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