Dexamethasone sodium phoshate, neomycin sulfate.
Each mL of drops contains dexamethasone sodium phosphate equivalent to dexamethasone phosphate 1 mg and neomycin sulfate equivalent to neomycin 3.5 mg.
Dexamethasone (dexamethasone sodium phosphate) diffuses across cell membrane and forms a complex with specific cytoplasmic receptors. These complexes then enter cell nucleus, bind to DNA, and stimulate transcription of mRNA. Subsequent protein synthesis of enzymes is ultimately responsible for the anti-inflammatory effects of topical application of corticosteroids to the eye. In high concentrations, which may be achieved after topical application, corticosteroids may exert direct membrane effects. Corticosteroids decrease cellular and fibrinous exudation and tissue infiltration, inhibit fibroblastic and collagen-forming activity, retard epithelial regeneration, diminish post-inflammatory neovascularization, and reduce toward normal levels the excessive permeability of inflamed capillaries.
Neomycin sulfate acts by interfering with bacterial protein synthesis.
Eye: Treatment of superficial ocular infection, involving the conjunctiva and/or cornea, caused by susceptible organisms.
Ear: Treatment of ear infection eg, otitis media and otitis externa.
Eye: 1-2 drops every 1-2 hrs.
Ear: 2-4 drops into auditory canal, every 2-4 hrs.
Hypersensitivity to neomycin sulfate and/or dexamethasone sodium phosphate.
Do not use in case of viral infection. May be used beyond a period of 1 month after opening.
S02CA06 - dexamethasone and antiinfectives ; Belongs to the class of combinations of corticosteroids and antiinfectives used in the treatment of ear diseases.
Eye/ear drops 5 mL (sterile) x 12's.