May exaggerate succinylcholine-type muscle relaxation during anesth. Patients w/ sick-sinus syndrome, supraventricular cardiac conduction conditions eg, SA or AV block, history of ulcer disease or those receiving concurrent NSAIDs; history of asthma or obstructive pulmonary disease. May exacerbate or induce extrapyramidal symptoms; cause bladder outflow obstruction. Avoid concomitant use w/ inhibitors of acetylcholinesterase, agonists or antagonists of the cholinergic system. Severe hepatic impairment. May affect ability to drive or operate machinery. Pregnancy & lactation. Not recommended for childn.