Atozin

Atozin

azithromycin

Manufacturer:

Millimed

Distributor:

Prosp Pharma
Concise Prescribing Info
Contents
Azithromycin dihydrate
Indications/Uses
Acute bacterial exacerbations of COPD, bacterial sinusitis & otitis media caused by H. influenzae, M. catarrhalis, S. pneumoniae. Community-acquired pneumonia caused by H. influenzae, M. pneumonia, S. pneumoniae, Chlamydophila pneumoniae. Genital ulcer disease (chancroid) in men caused by Haemophilus ducreyi. Pharyngitis/tonsillitis caused by S. pyogenes. Uncomplicated skin & skin structure infections caused by S. aureus, S. pyogenes, Strep agalactiae. Urethritis & cervicitis caused by Chlamydia trachomatis or Neisseria gonorrhea.
Dosage/Direction for Use
Adult Acute bacterial exacerbation of COPD 500 mg/day for 3 days. Alternative dose: 500 mg as a single dose on the 1st day followed by 250 mg once daily on days 2-5. Acute bacterial sinusitis 500 mg/day for 3 days. Community-acquired pneumonia 500 mg as a single dose on the 1st day followed by 250 mg once daily on day 2-5. Genital ulcer disease 1 g as single dose. Gonococcal urethritis/cervicitis 2 g as a single dose. Nongonococcal urethritis/cervicitis 1 g as a single dose. Pharyngitis/tonsillitis (as 2nd-line therapy) 500 mg as a single dose on the 1st day followed by 250 mg once daily on day 2-5. Uncomplicated skin/skin structure infections 500 mg as a single dose on the 1st day followed by 250 mg once daily on day 2-5. Childn ≥2 yr Pharyngitis/tonsillitis 12 mg/kg once daily for 5 days. Max dose: 500 mg/day, ≥6 mth Acute bacterial sinusitis 10 mg/kg once daily for 3 days. Acute otitis media 30 mg/kg given as a single dose. Alternative dose: 10 mg/kg once daily for 3 days or 10 mg/kg as a single dose on 1st day followed by 5 mg/kg on day 2-5. Community-acquired pneumonia 10 mg/kg as a single dose on the 1st day followed by 5 mg/kg on days 2-5.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity to azithromycin or other macrolide antibiotics.
Special Precautions
Preexisting liver disease, hepatic impairment w/ or w/o jaundice; renal dysfunction; myasthenia gravis. Discontinue use if malaise, nausea, vomiting, abdominal colic & fever symptoms occur. Perform culture & susceptibility test prior to initiation of therapy for masked or delayed symptoms of incubating gonorrhea or syphilis. Fungal or bacterial superinfection including C. difficile associated diarrhea & pseudomembranous colitis w/ prolonged use. Patients at risk of prolonged cardiac repolarization. Pregnancy & lactation.
Adverse Reactions
Diarrhea, nausea, abdominal pain, anorexia, cramping, vomiting, oral candidiasis, tongue discoloration; pruritus, rash; vaginitis, acute renal failure; arrhythmias, hypotension; aggressive reaction, anxiety, hyperactivity, parathesia, syncope; thrombocytopenia; cholestatic jaundice, rare case of hepatic necrosis & hepatic failure; hearing distrubances, taste loss & smell perversion; arthralgia & edema.
Drug Interactions
Avoid concomitant use w/ artemether, BCG, dronedarone, lumefantrine, nilotinib, pimozide, quinine. May increase effects of cardiac glycosides, cyclosporine, dronedarone, pimozide, QTc-prolonging agents, quinine, tacrolimus, tetrabenazine, thioridazine, vit K antagonist & ziprasidone. Effect may be increased by alfuzosin, artemether, chloroquine, ciprofloxacin, conivaptan, gadobutrol, lumefantrine, nilotinib & quinine. May decrease effects of BCG & typhoid vaccine.
MIMS Class
ATC Classification
J01FA10 - azithromycin ; Belongs to the class of macrolides. Used in the systemic treatment of infections.
Presentation/Packing
Form
Atozin cap 250 mg
Packing/Price
1 × 6's
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