Atropine Sulfate GPO

Atropine Sulfate GPO

atropine

Manufacturer:

GPO

Distributor:

GPO
Concise Prescribing Info
Contents
Atropine sulfate
Indications/Uses
Pre-op drug to control salivation & sputum overproduction induced by anaesth. Prevention of cholinergic effects caused by internal organ contraction, carotid sinus or some medications eg, succinylcholine during surgery; muscarinic effects induced by anticholinesterase used to inhibit neuromuscular block caused by curariform after surgery. In combination w/ cholinesterase reactivator eg, pralidoxime as antidote of cholinesterase inhibitors poisoning eg, neostigmine, pilocarpine, organophosphates, muscarine from poisonous mushroom. Reduce GI movement in process of GI endoscopy.
Dosage/Direction for Use
Adult Anticholinergic 0.4-0.6 mg by IV/IM/SC every 4-6 hr. Pre-op 0.4 mg (0.2-1 mg) by IM/SC 30-60 min prior to anesth administration. Intestinal movement reduction 1 mg by IM. Prevention of muscarinic effects induced by anticholinesterase used to inhibit neuromuscular block caused by curariform after surgery 0.6-1.2 mg by IV 2-3 min before or in the same time w/ neostigmine methylsulfate administration (0.5-2.5 mg). Antidote of cholinesterase inhibitors Initially 1.2 mg by IV & then IM or 2 mg IV every 5-10 min until muscarinic effects are controlled. Childn Anticholinergic 0.01 mg/kg IV/IM/SC (max dose: 0.4 mg/kg) every 4-6 hr. Pre-op 30-60 min IM/SC before anesth induction. ≥20 kg Same as adult dose, 12-16 kg 0.3 mg, 7-9 kg 0.2 mg, ≤3 kg 0.1 mg. Antidote of cholinesterase inhibitors Initially 1 mg IM/IV then 0.5-1 mg every 5-10 min until muscarinic effects are controlled.
Contraindications
Hypersensitivity. Glaucoma, myasthenia gravis, urinary tract obstruction.
Special Precautions
Discontinue use in presence of rapid heart rate, dizziness or blurred vision; weak patients. Down's syndrome & young patients w/ head trauma. GI tract infection, hyperthyroidism, CV diseases. Hepatic or renal impairment. Childn <6 yr. Elderly. Infants.
Adverse Reactions
Dry mouth, blurred vision, miosis, visual disturbance, urinary retention, bradycardia, tachycardia, constipation in elderly or weak patients, confusion, nervousness.
MIMS Class
ATC Classification
A03BA01 - atropine ; Belongs to the class of belladonna alkaloids, tertiary amines. Used in the treatment of functional gastrointestinal disorders.
Presentation/Packing
Form
Atropine Sulfate GPO inj 0.6 mg/mL
Packing/Price
1 mL x 50 × 1's
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