Great Eastern Drug


Zuellig Pharma
Concise Prescribing Info
Labetalol HCl
Control of BP in severe HTN including severe HTN of pregnancy.
Dosage/Direction for Use
Adult Repeated IV inj Initially, 20 mg slow IV inj over at 2 min period. Maintenance: Additional inj of 40 or 80 mg can be given at 10 min interval until desired supine BP is achieved or a total of 300 mg has been inj. Slow continuous infusion 50-200 mg: Total dose up to 300 mg may be required at a rate of 2 mg/min.
Hypersensitivity. Bronchial asthma, overt cardiac failure, > 1st-degree heart block, cardiogenic shock, severe bradycardia (<45-50 bpm), other conditions associated w/ severe & prolonged hypotension. History of obstructive airway disease including asthma. Low cardiac output due to peripheral vasoconstriction.
Special Precautions
Impaired hepatic function. History of severe anaphylactic reactions. Discontinue if jaundice or laboratory evidence of liver injury occurs. Avoid in overt CHF. History of heart failure, poorly controlled DM. Monitor blood glucose levels closely during therapy in patients w/ DM. Patients undergoing major surgery; severely elevated BP; avoid patients w/ low cardiac indices & elevated systemic vascular resistance; CABG surgery; high dose. Avoid upright position w/in 3 hr of administration. May affect ability to drive or operate machinery. Pregnancy & lactation. Childn. Elderly.
Adverse Reactions
Rash, pruritus, urticaria, angioedema, dyspnea & anaphylactoid reactions. Ventricular arrhythmia; dizziness, tingling of the scalp/skin, vertigo, hypesthesia; nausea, vomiting, dyspepsia, taste distortion; transient increases in BUN & serum creatinine levels; somnolence/yawning; wheezing; pruritus.
Drug Interactions
β-agonists, bronchodilators, Ca channel blockers. Increased bioavailability w/ cimetidine. Synergism may occur w/ halothane. White precipitate may be present w/ alkaline drugs (eg, furosemide). Additional antihypertensive effects may occur w/ nitroglycerin.
MIMS Class
ATC Classification
C07AG01 - labetalol ; Belongs to the class of alpha and beta blocking agents. Used in the treatment of cardiovascular diseases.
Avexa inj 5 mg/mL
20 mL x 1's
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