brinzolamide + timolol




Concise Prescribing Info
Per mL Brinzolamide 10 mg, timolol maleate 5 mg
Decrease IOP in open-angle glaucoma or ocular HTN when monotherapy is insufficient.
Dosage/Direction for Use
Adult including elderly 1 drop in the conjunctival sac of the affected eye(s) bid.
Bronchial asthma, severe COPD, sinus bradycardia; 2nd or 3rd degree AV block; overt cardiac failure or cardiogenic shock; severe allergic rhinitis & bronchial hyper-reactivity; hypersensitivity to sulphonamides & other β-blockers; hyperchloraemic acidosis; severe renal impairment.
Special Precautions
Control cardiac failure prior to therapy. History of severe cardiac & resp disease. Spontaneous hypoglycaemia or labile insulin-dependent diabetes. May mask signs & symptoms of acute hypoglycaemia, hyperthyroidism. May worsen Prinzmetal angina; severe peripheral & central circulatory disorders, hypotension. History of atopy or severe anaphylactic reaction to a variety of allergens. Close monitoring of IOP in patients w/ pseudoexfoliative glaucoma or pigmentary glaucoma. Narrow-angle glaucoma. Compromised corneas. Remove contact lenses prior to application & reinsert 15 min after instillation. Monitor patients w/ compromised corneas eg, w/ DM or corneal dystrophies. Close monitoring w/ frequent & prolonged use. May impair ability to drive or operate machinery. Pregnancy. Childn <18 yr.
Adverse Reactions
Dysgeusia, blurred vision; eye pain & irritation; foreign body sensation in eyes.
Drug Interactions
Oral carbonic anhydrase inhibitors; ketoconazole, itraconazole, clotrimazole, ritonavir, troleandomycin. Potential additive effect w/ oral Ca channel blockers, guanethidine or β-blockers, antiarrhythmics, digitalis glycosides or parasympathomimetics. β-blockers can potentiate hypertensive reaction to sudden w/drawal of clonidine. Potentiate systemic β-blockade w/ quinidine & cimetidine. May increase hypoglycaemic effect of antidiabetics.
ATC Classification
S01ED51 - timolol, combinations ; Belongs to the class of beta blocking agents. Used in the treatment of glaucoma.
Azarga ophth susp
5 mL x 1's
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