Azilect

Azilect

rasagiline

Manufacturer:

Lundbeck

Distributor:

B L Hua
Concise Prescribing Info
Contents
Rasagiline mesilate
Indications/Uses
Idiopathic parkinson's disease as monotherapy (w/o levodopa) or adjunct therapy (w/ levodopa) in patients w/ end of dose fluctuations.
Dosage/Direction for Use
1 mg once daily w/ or w/o levodopa.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity. Concomitant use w/ MAOIs (including St. John's wort) or pethidine. Severe hepatic impairment.
Special Precautions
Concomitant use w/ fluoxetine or fluvoxamine, dextromethorphan or sympathomimetics. At least 14 days should elapse between discontinuation of rasagiline & initiation of treatment w/ fluoxetine or fluvoxamine. Regularly monitor patients for the development of impulse control disorders (eg, compulsions, obsessive thoughts, pathological gambling, increased libido, hypersexuality, impulsive behaviour & compulsive spending or buying). Not recommended in concomitant use w/ dextromethorphan or sympathomimetics eg, those present in nasal & oral decongestants or cold medicinal products containing ephedrine or pseudoephedrine. May increase risk of melanoma in patients w/ longer duration of exposure &/or higher cumulative dose. Evaluate any suspicious skin lesion. Mild hepatic impairment. Avoid use in moderate hepatic impairment. Discontinue treatment if patient progresses from mild to moderate hepatic impairment. May cause daytime drowsiness, somnolence & falling asleep during activities of daily living. Possible additive effects w/ sedatives, alcohol, CNS depressants (eg, benzodiazepines, antipsychotics, antidepressants), ciprofloxacin. Do not drive, operate machinery, or work at heights during treatment. Pregnancy & lactation. Childn & adolescent.
Adverse Reactions
Headache, dyskinesia. Influenza; skin carcinoma; leucopenia; allergy; decreased appetite; depression, hallucinations, abnormal dreams; dystonia, carpal tunnel syndrome, balance disorder; conjunctivitis; vertigo; angina pectoris; rhinitis; flatulence, abdominal pain, constipation, nausea & vomiting, dry mouth; dermatitis, rash; musculoskeletal pain, neck pain, arthritis, arthralgia; urinary urgency; fever, malaise; orthostatic hypotension; decreased wt; fall.
Drug Interactions
May lead to hypertensive crises w/ MAOIs including St. John's wort. Not to be used w/ pethidine, sympathomimetics (eg, nasal & oral decongestants or cold medicinal products containing ephedrine or pseudoephedrine), dextromethorphan, fluoxetine or fluvoxamine, SSRIs, SNRIs, TCAs. Increased AUC w/ ciprofloxacin. May alter plasma levels w/ CYP1A2 inhibitors. Increased oral clearance w/ entacapone.
MIMS Class
Antiparkinsonian Drugs
ATC Classification
N04BD02 - rasagiline ; Belongs to the class of dopaminergic agents, monoamine oxidase B inhibitors. Used in the management of Parkinson's disease.
Presentation/Packing
Form
Azilect tab 1 mg
Packing/Price
4 × 7's
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