Adult Clinical vit B12 deficiency 1 tab daily. Severe cases Initially 2 tab daily. Severe neurological symptoms Initial parenteral application. Elderly Normal dose. Childn & adolescent Alternative to parenteral therapy of vit B12 deficiency Recommended dose: Up to 1,000 mcg daily.
Should be taken on an empty stomach: Preferably taken in the morning. Swallow whole w/ fluid.
Contraindications
Hypersensitivity. Patients w/ tobacco amblyopia or retrobulbar neuritis in pernicious anaemia. B12-deficient individuals who are at risk for Leber's optic atrophy.
Patients w/ folic acid deficiency. Galactose intolerance, lactase deficiency, glucose-galactose malabsorption, fructose intolerance or sucrase-isomaltase deficiency. Check for symptoms, reticulocyte & blood count (including Hb & haematocrit levels) & mean corpuscular vol (MCV) 7 days after initiation of treatment. Monitor for symptoms, blood count & MCV at 4-wkly intervals for 1st 3 mth of treatment, & at 6-mthly/annual intervals if patient compliance is good; more frequent controls if lack of patient compliance is suspected. Hepatic impairment. Not to be used for megaloblastic anaemia of pregnancy.
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