Bacticil

Bacticil

tigecycline

Manufacturer:

Intas Pharmaceuticals

Distributor:

Indochina Healthcare

Marketer:

Indochina Healthcare
Concise Prescribing Info
Contents
Tigecycline
Indications/Uses
Complicated skin & skin structure infections excluding diabetic foot infections; intra-abdominal infections in patients ≥18 yr.
Dosage/Direction for Use
Administer by IV infusion over 30-60 min. Adult Initially 100 mg followed by 50 mg every 12 hr for 5-14 days. Adolescents 12 to <18 yr 50 mg every 12 hr for 5-14 days. Childn 8 to <12 yr 1.2 mg/kg every 12 hr to a max of 50 mg every 12 hr for 5-14 days. Severe hepatic impairment (including ped) Reduce dose by 50%; Adult 25 mg every 12 hr following 100 mg loading dose.
Contraindications
Hypersensitivity to tigecycline or tetracyclines.
Special Precautions
Monitor for superinfection; patients on anticoagulants; liver function tests, coagulation & haematology parameters, amylase & lipase prior to & during therapy. Patients w/ impaired healing of the surgical wound. Anaphylaxis/anaphylactoid reactions. Discontinue if acute pancreatitis occurs. Severe underlying diseases. Concurrent bacteraemia; diabetic foot infection. Severely ill patients w/ complicated intra-abdominal infections secondary to clinically apparent intestinal perforation or patients w/ incipient sepsis or septic shock. Closely monitor patients presenting w/ cholestasis. Pseudomembranous colitis. May cause permanent tooth discolouration if used during tooth development. Severe hepatic impairment. May affect ability to drive & operate machinery. Pregnancy & lactation. Childn <8 yr.
Adverse Reactions
Nausea, vomiting, diarrhoea. Sepsis/septic shock, pneumonia, abscess, infections, prolonged activated partial thromboplastin time & PT; hypoglycaemia, hypoproteinaemia; dizziness; phlebitis; abdominal pain, dyspepsia, anorexia; elevated AST & ALT serum, hyperbilirubinaemia; pruritus, rash; impaired healing, inj site reaction, headache; elevated serum amylase, increased BUN.
Drug Interactions
May decrease clearance & increase AUC of warfarin. Concomitant use w/ OC may render OC less effective. Pharmacokinetics may be affected by P-gp inhibitors (eg, ketoconazole or cyclosporine) or P-gp inducers (eg, rifampicin).
MIMS Class
ATC Classification
J01AA12 - tigecycline ; Belongs to the class of tetracyclines. Used in the systemic treatment of infections.
Presentation/Packing
Form
Bacticil powd for infusion 50 mg
Packing/Price
10 × 1's
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