Adult: Acute uncomplicated influenza: 40-<80 kg: 40 mg; ≥80 kg: 80 mg. Given as single dose, initiate within 48 hours after the onset of symptoms. Child: Acute uncomplicated influenza: ≥12 years Same as adult dose.
May be taken with or without food. Avoid taking w/ dairy products, Ca-fortified beverages, polyvalent cation-containing laxatives, antacids or oral
supplements containing Ca, Fe, Mg, Se, or Zn.
Patients with known hypersensitivity to baloxavir marboxil.
Pregnancy and lactation. Avoid concomitant administration with products containing polyvalent cations (e.g. calcium, magnesium, iron, selenium, zinc).
Monitor for possible secondary bacterial infections.
Reduced absorption and decreased serum concentration with polyvalent cation-containing products (e.g. calcium, iron, magnesium, selenium, zinc). May diminish the effect of live/attenuated influenza virus vaccine.
Reduced absorption with dairy products.
Description: Baloxavir marboxil is a prodrug that is converted to baloxavir, the active form that exerts anti-influenza virus activity. It inhibits the endonuclease activity of the polymerase acidic protein, which is necessary for viral gene transcription, thus inhibiting influenza virus replication. Pharmacokinetics: Absorption: Time to peak plasma concentration: 4 hours. Distribution: Volume of distribution: 1,180 L. Plasma protein binding: Approx 93-94%. Metabolism: Completely metabolised mainly by UGT1A3 (major) and CYP3A4 (minor) to active metabolite, baloxavir. Excretion: Via faeces (80.1%); urine (14.7%; 3.3% as baloxavir). Elimination half-life: 79.1 hour.
J05AX25 - baloxavir marboxil ; Belongs to the class of other antivirals. Used as a direct acting antiviral in the systemic treatment of viral infections.
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