The vaccine should not be given to persons who showed a severe reaction to a previous dose of Diphtheria and Tetanus Vaccine.
A history of systemic allergic or neurologic reactions following a previous dose of Td is an absolute contraindication for further use.
Immunization should be deferred during the course of an acute illness. Vaccination of persons with severe, febrile illness should generally be deferred until these persons have recovered. However, the presence of minor illnesses such as mild upper respiratory infections with or without fever should not preclude vaccination.