Betaloc Zok

Betaloc Zok





Concise Prescribing Info
Metoprolol succinate
Reduce BP & risk of CV, & coronary mortality (including sudden death) & morbidity. Angina pectoris. Cardiac arrhythmias especially including supraventricular tachycardia, reduction of ventricular rate in atrial fibrillation & in ventricular extrasystoles. Migraine prophylaxis. Prevention of cardiac death & reinfarction after the acute phase of MI.
Dosage/Direction for Use
Mild to moderate HTN 50 mg once daily. Patients unresponsive to 50-mg dose May be increased to 100-200 mg once daily &/or combined w/ other antihypertensive agents. Angina pectoris 100-200 mg once daily. May be combined w/ other antianginal agents if needed. Cardiac arrhythmias & migraine prophylaxis 100-200 mg once daily. Prophylactic treatment after MI 200 mg once daily. Functional heart disorders w/ palpitations 100 mg once daily. May be increased to 200 mg if needed.
May be taken with or without food: Preferably taken in the morning. Swallow whole w/ liqd, do not chew/crush tab & divided halves.
Hypersensitivity to metoprolol or other β-blockers. Patients w/ 2nd- or 3rd-degree AV block, unstable decompensated cardiac heart failure (pulmonary oedema, hypoperfusion or hypotension), continuous or intermittent inotropic therapy acting through β-receptor agonism, marked clinically relevant sinus bradycardia, sick sinus syndrome (unless permanent pacemaker is in place), cardiogenic shock, severe peripheral arterial circulatory disorder. Not to be given to patients w/ suspected acute MI as long as the heart rate is <45 beats/min, the PQ interval is >0.24 sec or the systolic BP is <100 mmHg.
Special Precautions
Should not be given w/ IV administration of verapamil-type Ca antagonists. Adjust β2-agonist dose in concomitant treatment w/ Betaloc ZOK in treating patients w/ asthma. Treat heart failure decompensation before & during treatment. May aggravate moderate preexisting AV conduction disorder (possibly leading to AV block); peripheral arterial circulatory disorders symptoms. Gradually w/draw or give in lower doses if increasing bradycardia develops. Administer concomitant α-blocker in patients suffering from phaeochoromocytoma. Gradually w/draw dose at least 2 wk into half doses until final dose is ½ tab of 50 mg & give for at least 4 days before discontinuation. Inform anaesth of the therapy prior to surgery. Discontinuation of β-blocker treatment is not recommended in patients undergoing surgery. Avoid acute initiation of high-dose therapy to patients undergoing non-cardiac surgery; abrupt interruption of the medication. More severe form of anaphylactic shock. Dizziness or fatigue may occur & may affect the ability to drive & use machines. Serious hepatic impairment. Perform maternofetal monitoring to pregnant women on treatment. Pregnancy & lactation. May cause bradycardia in foetus, newborn & breast-fed infant. Childn.
Adverse Reactions
Fatigue. Bradycardia, postural disorders, cold hands & feet, palpitations; dizziness, headache; nausea, abdominal pain, diarrhoea, constipation; dyspnoea on exertion.
Drug Interactions
May increase plasma levels w/ antiarrhythmics, antihistamines, H2-receptor antagonists, antidepressants, antipsychotics, COX-2 inhibitors; alcohol & hydralazine. May lower plasma conc w/ rifampicin. Concomitant use w/ sympathetic ganglion blocking agents, other β-blockers (ie, eye drops), or MAOIs & clonidine. Possible negative inotropic & chronotropic effects w/ Ca antagonists (verapamil- & diltiazem-type) &/or antiarrhythmic agents. May enhance negative inotropic & negative dromotropic effect of antiarrhythmic agents (of the quinidine type & amiodarone). May increase AV conduction time & induce bradycardia w/ digitalis glycosides. May enhance cardiodepressant effect w/ inhalation anaesth. May decrease antihypertensive effect in concomitant use w/ indomethacin or other prostaglandin synthetase inhibiting drugs.
MIMS Class
ATC Classification
C07AB02 - metoprolol ; Belongs to the class of selective beta-blocking agents. Used in the treatment of cardiovascular diseases.
Betaloc Zok CR tab 100 mg
2 × 15's
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Sign up for free
Already a member? Sign in