Liver or renal disorder. Risk of serious CV thrombolic events, MI or stroke; serious GI adverse effects including upper GI perforations, ulcers or bleeding. PUD, GI bleeding, bleeding abnormalities, impaired renal function. HTN, or compromised cardiac function. Severe renal & hepatic impairment (contraindicated). Discontinue if skin rashes & flu-like syndrome occurs. Risk of cerebrovascular disease & CHD especially in prolonged period high-dose therapy. Avoid in patients suspected of haemorrhagic fever or platelet abnormalities. Childn <12 yr; infants up to 6 mth. Pregnancy (avoid especially 3rd
trimester) & lactation. Elderly.