Concise Prescribing Info
Relief of fever (not caused by dengue virus). Analgesic & anti-inflammatory effect eg, in RA & OA, for relief of mild to moderate pain eg, dysmenorrhea.
Dosage/Direction for Use
Adult & childn >12 yr Tab dosage form is recommended. Childn 6 mth to 12 yr Antipyretic 5-10 mg/kg every 4-6 hr. Max: 40 mg/kg/day. Childn 6-12 yr 2-4 tsp every 6-8 hr & not  more than qid, 3-6 yr 1-2 tsp every 6-8 hr & not more than qid, 1-3 yr ½-1 tsp every 6-8 hr & not more than qid.
Should be taken with food.
Hypersensitivity to ibuprofen or other NSAIDs. Hemorrhagic fever caused by dengue virus. Treatment of peri-operative pain in CABG surgery.
Special Precautions
Liver or renal disorder. Risk of serious CV thrombolic events, MI or stroke; serious GI adverse effects including upper GI perforations, ulcers or bleeding. PUD, GI bleeding, bleeding abnormalities, impaired renal function. HTN, or compromised cardiac function. Severe renal & hepatic impairment (contraindicated). Discontinue if skin rashes & flu-like syndrome occurs. Risk of cerebrovascular disease & CHD especially in prolonged period high-dose therapy. Avoid in patients suspected of haemorrhagic fever or platelet abnormalities. Childn <12 yr; infants up to 6 mth. Pregnancy (avoid especially 3rd trimester) & lactation. Elderly.
Adverse Reactions
Dyspepsia, heartburn, nausea, vomiting, anorexia, mucositis, diarrhea, constipation, flatulence, epigastric & abdominal pain, peptic ulcer, & GI bleeding. Edema, dizziness, headache, nervousness, & tinnitus.
Drug Interactions
Increase prothrombin time w/ anticoagulants eg, warfarin. Increased serum conc w/ cyclosporin, digoxin, methotrexate. Increase plasma conc of lithium. Decreased efficacy w/ antihypertensive drugs including diuretics, ACE inhibitors, angiotensin antagonists.
ATC Classification
M01AE01 - ibuprofen ; Belongs to the class of propionic acid derivatives of non-steroidal antiinflammatory and antirheumatic products.
Bunofen oral susp 100 mg/5 mL
60 mL x 1's
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