SRS Pharmaceuticals


DCH Auriga


Concise Prescribing Info
Complicated skin & skin structure infections caused by E. coli, Enterococcus faecalis (vancomycin-susceptible isolates only), Staph aureus (methicillin-susceptible & resistant isolates), Strep agalactiae, Strep anginosus group (including S. anginosus, S. intermedius & S. constellatus), Strep pyogenes & Bacteroides fragilis. Complicated intra-abdominal infections caused by Citrobacter freundii, Enterobacter cloacae, E. coli, Klebsiella oxytoca, Klebsiella pneumoniae, Enterococcus faecalis (vancomycin-susceptible isolates only), Staph aureus (methicillin-susceptible isolates only), Strep anginosus group (including S. anginosus, S. intermedius & S. constellatus), Bacteroides fragilis, Bacteroides thetaiotaomicron, Bacteroides uniformis, Bacteroides vulgatus, Clostridium perfringens, Peptostreptococcus micros.
Dosage/Direction for Use
Initially 100 mg followed by 50 mg 12 hrly IV infusion approx 30-60 min for 5-14 days. Severe hepatic impairment Initially 100 mg followed by a reduced maintenance dose of 25 mg 12 hrly.
Hypersensitivity to tetracycline class antibiotics.
Special Precautions
Patients w/ complicated intra-abdominal infection secondary to clinically apparent intestinal perforation. Pancreatitis; superinfection may occur w/ concomitant use w/ other antibacterial drugs. May cause permanent teeth discoloration during tooth development (last half of pregnancy, infancy & childhood 8 yr).  Mild diarrhea to fetal colitis. Pregnancy & lactation.
Adverse Reactions
Nausea, vomiting & diarrhea. Abscess, abdominal pain, anorexia, dyspepsia, dizziness, headache, phlebitis, pruritus & rash. Sepsis or septic shock. Raised liver enzymes, bilirubinaemia, increased serum amylase & BUN. Local reaction at infusion site, thrombocythaemia, anaemia & leucocytosis. Acute pancreatitis.
Drug Interactions
Increased Cmax & AUC & decreased clearance of R-warfarin & S-warfarin w/ warfarin.
MIMS Class
ATC Classification
J01AA12 - tigecycline ; Belongs to the class of tetracyclines. Used in the systemic treatment of infections.
Capessa infusion 50 mg
5 mL x 1's
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