Cardepine

Cardepine

nicardipine

Manufacturer:

Great Eastern Drug

Distributor:

Zuellig Pharma
Concise Prescribing Info
Contents
Nicardipine HCl
Indications/Uses
SR cap: Angina pectoris; essential HTN (alone or in combination); cerebrovascular insufficiency due to spasms & arteriosclerosis; cerebrovascular apoplexy as in thrombosis & embolism; cerebral anoxia following intracranial causes like shock secondary to cardiopulmonary arrest & hemorrhage; cerebral vasospasm after aneurysmal subarachnoid hemorrhage. Inj: Moderate to severe HTN where immediate correction of BP is required (eg, hypertensive emergency or urgencies). Peri-op & post-op HTN. Short-term treatment of essential HTN when oral therapy is not feasible or desirable.
Dosage/Direction for Use
SR cap Angina, essential HTN, adjunct in the management of CHF & cerebrovascular disorders 1-2 cap daily. May be increased to 3 cap daily if desired response is not reached. Inj Administer as slow continuous IV infusion at a conc of 0.1 mg/mL. Patients not currently receiving antihypertensive therapy 0.1 mg/mL as slow continuous IV infusion. Gradual BP reduction Initially 5 mg/hr. Increase infusion rate by 2.5 mg/hr every 15 min if optimal BP is not achieved at initial dose. Max dose: 15 mg hr. Maintenance dose: Adjust infusion rate as needed to maintain desired response. More rapid BP reduction Initially 5 mg/hr. Increase infusion rate by 2.5 mg/hr every 5 min if optimal BP is not achieved at initial dose. Max dose: 15 mg/hr. Maintenance dose: Adjust infusion rate as needed to maintain desired response. Following achievement of BP goal, decrease infusion rate to 3 mg/hr.
Administration
Should be taken with food: Avoid grapefruit juice 1 hr before or 2 hr after a dose. Avoid taking w/ high fat meals. Swallow whole, do not crush/chew.
Contraindications
SR cap: Intracranial hemorrhage in whom hemostasis is presumed to be unfinished & those in acute phase of cerebral apoplexy w/ increased intracranial pressure. Inj: Hypersensitivity. Advanced aortic stenosis.
Special Precautions
Liver & kidney function impairment. Pregnancy & lactation. SR cap: Hypotension; glaucoma. Inj: Carefully monitor BP & heart rate. Patients w/ acute cerebral infraction or hemorrhage & systemic hypotension; angina; CHF especially in those receiving concomitant β-adrenergic blocking agents. Pheochromocytoma. Avoid administering in arteries or small peripheral veins. Pregnancy & lactation. Childn <18 yr. Elderly.
Adverse Reactions
SR cap: Nausea, anorexia, heartburn, constipation, diarrhea, headache, salivation, pollakiuria, facial flush, heat sensation, palpitation, edema of the lower limbs & lassitude. Inj: Asthenia, chest pain, fever, neck pain, malaise, fatigue, peripheral or facial edema, infection, arthralgia; hypotension, postural hypotension, exertional, hypotension, tachycardia, ECG abnormality, ventricular extrasystoles, extrasystoles, hemopericardium, HTN, supraventricular tachycardia, syncope, vasodilation, ventricular tachycardia, angina pectoris, AV block, ST segment depression, inverted T-wave, deep-vein thrombophlebitis, sick sinus syndrome, flushing, palpitations, MI, atrial fibrillation, pericarditis, peripheral vascular disorder; abdominal pain, nausea, vomiting, dyspepsia; constipation, diarrhea, dry mouth, anorexia, heartburn; hypokalemia, hypophosphatemia, hyperglycemia, abnormal hepatic function test results, increased plasma renin conc; headache, dizziness, hyperthesia, intracranial hemorrhage, paresthesia, confusion, hypertonia, somnolence, insomnia, hot flashes, vertigo, hyperkinesia, impotence, mental depression, anxiety, CVA, cerebral ischemia, lassitude, nervousness, lightheadedness; thrombocytopenia; dyspnea, resp disorder, rhinitis, sinusitis; sweating, inj site reaction & pain, rash; polyuria, hematuria, increased urinary frequency, nocturia, urinary retention; conjunctivitis, abnormal or blurred vision, ear disorder, tinnitus.
Drug Interactions
Excessive decrease in BP & reduction of cardiac function in patients w/ CHF w/ β-blockers (eg, propranolol). Increased plasma levels w/ cimetidine. May increase plasma levels of digoxin & ciclosporin. May cause hypotension w/ fentanyl. Other antihypertensive agents.
MIMS Class
Calcium Antagonists / Cardiac Drugs
ATC Classification
C08CA04 - nicardipine ; Belongs to the class of dihydropyridine derivative selective calcium-channel blockers with mainly vascular effects. Used in the treatment of cardiovascular diseases.
Presentation/Packing
Form
Cardepine infusion 10 mg/10 mL
Packing/Price
10 × 1's
Form
Cardepine infusion 2 mg/2 mL
Packing/Price
10 × 1's
Form
Cardepine SR cap 40 mg
Packing/Price
30's
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