Chlorpheniramine GPO

Chlorpheniramine GPO

chlorphenamine

Manufacturer:

GPO

Distributor:

GPO
Full Prescribing Info
Contents
Chlorpheniramine maleate.
Description
Injection: Each mL contains Chlorpheniramine maleate 10 mg.
Action
Pharmacology: Injection: Chlorpheniramine is a propylamine-derivative antihistamine used in the treatment of allergy.
It acts by competing with with histamine for H1-receptor sites of effector cells.
Following IV administration in human, chlorpheniramine undergoes rapid and extensive distribution. The apparent steady-state volume of distribution is 2.5-3.2 L/kg in adults and 3.8 L/kg in children. The elimination half-life of the drug is about 12-23 hours in adults and 5.2-23.1 hours in children. Chlorpheniramine is metabolized in the liver. The drug and its metabolites are excreted almost completely in urine.
Indications/Uses
Syrup: Allergy including rash, urticaria and runny nose.
Injection: Chlorpheniramine injection is used in the treatment of allergy such as allergic rhinitis, pruritus and indicated as adjunctive therapy for anaphylactic reaction.
Dosage/Direction for Use
Syrup: Adult: 10 mL orally 3-4 times daily. Children (6-12 years): 5 mL orally 3-4 times daily or as directed by doctor.
Injection: Adults: For the relief of allergic reactions: IV, IM or subcutaneous, 10-20 mg as single dose.
For the adjunctive therapy of anaphylaxis: IV, 10-20 mg as a single dose.
For the treatment of uncomplicated allergic conditions: 5-20 mg as a single dose.
Children: Subcutaneous, 0.0875 mg/kg or 2.5 mg/m2 every six hours as needed.
Note: The maximum adult dosage is 40 mg daily.
Intramuscular injections should be administered deeply into the muscle.
Intravenous injections should be administered slowly, preferably with the patient in recumbent position.
Chlorpheniramine injection is not recommended for used in children under 1 year of age, premature and full-term neonates.
Contraindications
Syrup: Children under 1 year. Patients with asthma exacerbation, glaucoma, benign prostatic hypertrophy or urinary incontinence unless being directed by doctor.
Warnings
Injection: May cause drowsiness, avoid driving, operating machines, or doing jobs requiring alertness.
Caution is recommended when concomitantly used with CNS depressive drugs such as benzodiazepines; anticholinergic drug and antidepressants.
Used with caution in patients with hypertension, cardiovascular diseases, hyperthyroidism, patients with history of bronchial asthma, emphysema.
Use in Pregnancy & Lactation: Use with caution in pregnant women during first trimester and in nursing women.
Special Precautions
Syrup: Alcohol consumption or taking drug containing alcohol is not recommended; hypertension, cardiovascular diseases, hyperthyroidism, history of asthma or emphysema.
Effects on the Ability to Drive or Operate Machinery: Product can cause drowsiness, driving or operating machine is note recommended while taking it.
Use in Pregnancy & Lactation: Should be used with caution in first-trimester pregnancy, breastfeeding women.
Use in Children: Children and elderly are more sensitive to adverse reaction of this product.
Use In Pregnancy & Lactation
Use with caution in first-trimester in pregnancy & breastfeeding women.
Adverse Reactions
Syrup: Drowsiness, thick sputum, dry mouth, urinary incontinence, dizziness, hallucination, hypotension, restlessness, insomnia, paradoxical reaction.
Injection: Drowsiness, thickening of mucus and dry mouth may occur.
Drug Interactions
Syrup: Alcohol consumption, CNS depressants (e.g. benzodiazepines, anticholinergics, antidepressants).
Storage
Injection: Store below 25°C, protect from light.
ATC Classification
R06AB04 - chlorphenamine ; Belongs to the class of substituted alkylamines used as systemic antihistamines.
Presentation/Packing
Syr 2 mg/5 mL x 60 mL x 1's. Inj (amp) 10 mg/mL x 50 x 1's.
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