Benign gastric and duodenal ulceration, Zollinger-Ellison syndrome
Adult: Intermittent infusion: 300 mg 6-8 hrly infused over 15-20 min. Max: 2400 mg/day. Continuous infusion: 37.5 mg/hr (900 mg/day). A 150 mg IV loading dose may be given in patients requiring rapid elevation of gastric pH.
Prophylaxis of gastrointestinal haemorrhage from stress ulceration
Adult: 200-400 mg 4-6 hrly.
Benign gastric and duodenal ulceration
Adult: 800 mg daily at bedtime or 400 mg bid for at least 4 wk for duodenal ulcers, 6 wk for gastric ulcers and 8 wk for NSAID-associated ulcers. May increase to 400 mg 4 times daily if necessary. Maintenance: 400 mg daily at bedtime or bid.
Adult: 800-1600 mg/day in 4 divided doses, taken 60-90 min before meals.
Adult: Max: 800 mg/day in divided doses.
Adult: 300 or 400 mg 4 times daily, increase dose if necessary.
Gastro-oesophageal reflux disease
Adult: 400 mg 4 times daily or 800 mg bid for 4-12 wk.
Prophylaxis of acid aspiration during general anaesthesia
Adult: 400 mg given 90-120 minutes before induction of anaesth or at the start of labour. Dose up 400 mg may be repeated 4 hourly if necessary. Max daily dose: 2.4 g.
Short bowel syndrome
Adult: Initially, 400 mg bid, adjusted according to response.