Cipol-N

Cipol-N

ciclosporin

Manufacturer:

Chong Kun Dang

Distributor:

SPS Medical
Concise Prescribing Info
Contents
Cyclosporin A microemulsion
Indications/Uses
RA, nephrotic syndrome, psoriasis, atopic dermatitis. Solid organ & bone marrow transplantion.
Dosage/Direction for Use
Solid organ transplantation Initially 10-15 mg/kg in 2 divided doses 12 hr before surgery. Maintainance: 2-6 mg/kg in 2 divided doses. RA Initially 2.5 mg/kg in 2 divided doses daily. May be increased by 0.5-0.75 mg/kg daily after 8 wk & to a max of 4 mg/kg daily after 12 wk. Nephrotic syndrome Initial dose should not exceed 2.5 mg/kg/day. May be increased to approx 5 mg/kg/day in adults & 6 mg/kg/day in childn. Psoriasis Initially 1.25 mg/kg bid. May be increased in increments to a max of 4 mg/kg.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity. Renal impairment, uncontrolled HTN, malignancies. Concomitant use w/ PUVA or UVB, methotrexate, other immunosuppressive agents, coal tar or radiation therapy in psoriasis patients.
Special Precautions
Close monitoring of renal & hepatic function parameters (eg, BUN, serum creatinine, bilirubin & liver enzyme conc). May cause nephrotoxicity &/or hepatotoxicity. Avoid excessive UV light exposure.
Adverse Reactions
HTN, headache, hirsutism, hypertrichosis, gum hyperplasia, tremor, renal dysfunction.
Drug Interactions
May potentiate renal dysfunction w/ aminoglycosides, vancomycin, co-trimoxazole, ciprofloxacin, amphotericin B, ketoconazole, diclofenac, naproxen, sulindac, cimetidine, ranitidine, fibric acid derivatives (eg, fenobrate, methotrexate, colchicine, & tacrolimus).
ATC Classification
L04AD01 - ciclosporin ; Belongs to the class of calcineurin inhibitors. Used as immunosuppressants.
Presentation/Packing
Form
Cipol-N soft-gelatin cap 25 mg
Packing/Price
10 × 5's
Form
Cipol-N soft-gelatin cap 100 mg
Packing/Price
10 × 5's
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