Ciprobay

Ciprobay Dosage/Direction for Use

ciprofloxacin

Manufacturer:

Bayer HealthCare Pharma

Distributor:

DKSH
Full Prescribing Info
Dosage/Direction for Use
Unless otherwise prescribed, guide doses in Table 4 are recommended: See Table 4.

Click on icon to see table/diagram/image
In particularly serious infections (eg, recurrent infections in patients with mucoviscidosis, pneumonias, infections of the abdominal cavity, bones and joints) caused by Pseudomonas, Staphylococcus or Streptococcus pneumoniae and in acute pneumonia due to Streptococcus pneumoniae, the daily dose has to be increased to 2 x 750 mg orally where the patient is not being treated IV.
Urinary Tract Infections caused by Chlamydia: The daily dose should be increased, if necessary, to 2 x 750 mg (oral).
CAPD Patients with Peritonitis: The recommended daily oral dose is 500 mg 4 times a day or intraperitoneal 50 mg/L dialysate 4 times a day.
Up to 500 mg (oral) can be given as a single daily dose when uncomplicated urinary tract or gastrointestinal infections are present.
Acute Gonorrhea in Women and Men and Acute Uncomplicated Cystitis in Women: Can be treated with a single dose of 250 mg (orally) or 100 mg (IV).
Elderly Patients: Should receive a dose as low as possible; this will depend on the severity of the illness and on the creatinine clearance.
If the patient is unable to take tablets, because of the severity of his illness or for other reasons, it is recommended to commence the therapy with an IV form of Ciprobay.
After IV administration, the treatment can be continued orally.
Renal and Hepatic Impairment: 1. Impaired Renal Function: (1.1) Where creatinine clearance is between 31 and 60 mL/min/1.73 m2 or where the serum creatinine concentration is between 1.4 and 1.9 mg/100 mL, the maximum daily dose should be 1000 mg/day for oral and 800 mg/day for an IV regimen. (1.2) Where creatinine clearance is ≤30 ml/min/1.73 m2 or where the serum creatinine concentration is ≥2 mg/100 mL, the maximum daily dose should be 500 mg/day for oral and 400 mg/day for an IV regimen.
2. Impaired Renal Function + Haemodialysis: Dose as in 1.2; on dialysis days after dialysis.
3. Impaired Renal Function + CAPD: Oral: Administration of ciprofloxacin film-coated tablets as 1 x 500-mg film-coated tablet (or 2 x 250-mg film-coated tablets).
IV: Addition of ciprofloxacin infusion solution to the dialysate (intraperitoneal): Ciprofloxacin 50 mg/L dialysate administered 4 times a day every 6 hrs.
4. Impaired Liver Function: No dose adjustment is required.
5. Impaired Renal and Liver Function: Dose adjustment as in 1.1 and 1.2.
Administration: Oral: The tablets should be swallowed whole with liquid. They may be taken independently of mealtimes. (If the tablets are taken on an empty stomach, the active substance is absorbed more quickly.)
IV: IV infusion over a period of approximately 60 min.
The infusion solution can be infused either directly or after mixing with other infusion solutions.
The infusion solution is compatible with physiological saline, Ringer's solution and Ringer's lactate solution, 5% and 10% glucose solutions, 10% fructose solution, and 5% glucose solution with 0.225% NaCl or 0.45% NaCl.
Duration of Administration: The duration of treatment depends on severity of the illness and on the clinical and bacteriological course. It is essential to continue the treatment for at least 3 days after disappearance of the fever or of the clinical symptoms.
Mean Duration of Treatment: 1 day for acute uncomplicated gonorrhea and cystitis, up to 7 days for infections of the kidneys, urinary tract and abdominal cavity, over the entire period of the neutropenic phase in patients with weakened body defenses, a maximum of 2 months in osteomyelitis, and 7-14 days in all other infections.
In streptococcal infections the treatment should last at least 10 days because of the risk of late complications.
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