The following side effects have been observed:
Common: ≥1% to <10%; uncommon: ≥0.1% to <1%; rare: ≥0.01% to <0.1%; very rare: <0.01%.
Infections and Infestations: Candida infections are uncommon. Antibiotic-associated colitis is rare (very rarely with possible fatal outcome).
Blood and Lymphatic System Disorders: Eosinophilia is uncommon. Leukopenia, anemia, neutropenia, leukocytosis, thrombocytopenia and thrombocythemia are rare. Hemolytic anemia, agranulocytosis, pancytopenia (life-threatening), and bone marrow depression (life-threatening) are very rare.
Immune System Disorders: Allergic reaction, allergic edema/angioedema are rare. Anaphylactic reaction, anaphylactic shock (life-threatening) and serum sickness-like reactions are very rare.
Metabolism and Nutrition Disorders: Anorexia is uncommon. Hyperglycemia is rare.
Psychiatric Disorders: Psychomotor hyperactivity/agitation is uncommon. Confusion and disorientation, anxiety reaction, abnormal dreams, depression and hallucinations are rare. Psychotic reactions are very rare.
Nervous System Disorders: Headache, dizziness, sleep disorders and taste disorders are uncommon. Paraesthesia and dysaesthesia, hypoaesthesia, tremor, seizures and vertigo are rare. Migraine, disturbed coordination, smell disorders, hyperesthesia and intracranial hypertension are very rare.
Eye Disorders: Visual disturbances are rare. Visual color distortions are very rare.
Ear and Labyrinth Disorders: Tinnitus and hearing loss are rare. Hearing impairment is very rare.
Cardiac Disorders: Tachycardia is rare.
Vascular Disorders: Vasodilatation, hypotension and syncope are rare. Vasculitis is very rare.
Respiratory, Thoracic and Mediastinal Disorders: Dyspnea (including asthmatic condition) is rare.
Gastrointestinal Disorders: Nausea and diarrhea are common. Vomiting, gastrointestinal and abdominal pains, dyspepsia and flatulence are uncommon. Pancreatitis is very rare.
Hepatobiliary Disorders: Transient increase in transaminases and increased bilirubin are uncommon. Transient hepatic impairment, jaundice and hepatitis (non-infective) are rare. Liver necrosis (very rarely progressing to life-threatening hepatic failure) is very rare.
Skin and Subcutaneous Tissue Disorders: Rash, pruritus and urticaria are uncommon. Photosensitivity reactions and unspecific blistering are rare. Petechiae, erythema multiforme minor, erythema nodosum, Stevens-Johnson syndrome and toxic epidermal necrolysis are very rare.
Musculoskeletal, Connective Tissue and Bone Disorders: Arthralgia is uncommon. Myalgia, arthritis and increased muscle tone and cramping are rare. Muscular weakness, tendonitis, tendon rupture (predominantly Achilles tendon) and exacerbation of symptoms of myasthenia gravis are very rare.
Renal and Urinary Disorders: Renal impairment is uncommon. Tubulointerstitial nephritis, renal failure, hematuria and crystalluria are rare.
General Disorders and Administration Site Conditions: Injection and infusion site reactions (only IV administration) are common. Unspecific pain, feeling unwell and fever are uncommon. Edema and sweating (hyperhidrosis) are rare. Gait disturbance is very rare.
Investigations: Transient increase in blood alkaline phosphatase is uncommon. Abnormal prothrombin level and increased amylase are rare.