AdultMild infection 600 mg/day in 2 divided doses. Moderate serious infection 600-1,200 mg/day in 2-4 divided doses. More serious infection 1.2-2.7 g/day in 2-4 divided doses, may be increased to 4.8 g/day IV in life-threatening situations. Childn >1 mth 20-40 mg/kg body wt/day in 3-4 divided doses. Serious infection 350 mg/m2/day. More serious infection 450 mg/m2/day. Neonates <1 mth 15-20 mg/kg body wt/day in 3-4 divided doses.
Contraindications
Hypersensitivity to clindamycin or lincomycin.
Special Precautions
Diarrhea; liver & renal impairment. Perform periodic liver & kidney function tests & blood counts during prolonged therapy. Severe renal or hepatic disease accompanied by severe metabolic aberrations.
Adverse Reactions
Pain, induration & sterile abscess after IM inj & thrombophlebitis after IV infusion; sensitivity reactions eg, contact dermatitis, pruritus, erythematous, papular & nodular eruption; nausea, vomiting, diarrhea, abdominal pain, bloody diarrhea, colitis; abnormalities in liver function test; polyarthritis; cardiopulmonary arrest & hypotension following too rapid IV administration; transient neutropenia & eosinophilia.
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