Clodronic Acid - Intravenous

Patient Medicine Information
Why do I need this medicine?
Clodronic Acid injection is used to strengthen and protect the bones from further damage.

Clodronic Acid injection is used to treat bone diseases that occur together with certain types of cancers.

Clodronic Acid injection helps to prevent calcium from leaking out of your bones. It helps to strengthen your bones and reduce the chances of getting fractures and bone pain. It also helps to lower the level of calcium in the bloodstream -- this helps to prevent metabolic disturbances.
How do I use this medicine?
Clodronic Acid injection is to be given intravenously (into the vein). It is delivered directly into the bloodstream via the blood vessel.

Your doctor or nurse will administer the injection for you. The injection is usually given over a period of 2-6 hours via a drip. It may be given just once only, or it may be given everyday for about 7 days.

Clodronic Acid injection is given when you are not able to swallow pills or if you need urgent treatment for your condition. Your doctor will advise you when you can switch from the injection to the pills.
What should I do if I have forgotten to take this medicine?
Keep all appointments with your doctor. Your doctor needs to monitor your condition and check your response to the medication regularly.

If you miss a dose of your injection, arrange to have it administered as soon as possible.

If you often miss your scheduled injection, let your doctor and pharmacist know.
When should I not use this medicine?
Alert your doctor if you have gastric problems such as gastritis (inflammation of the lining of the stomach), as Clodronic Acid may not be suitable for you.

Do not use Clodronic Acid injection if you are taking other similar medicines such as pamidronate, alendronate, risedronate or zoledronate.
What should I take note of while using this medicine?
Inform your doctor if you:

- have kidney disease
- have difficulty in swallowing
- have disease of the gullet (food pipe), heartburn (food or acid from stomach backs up into your mouth, leaving a sour or bitter taste), stomach ulcers

Let your doctor know if you are pregnant or breastfeeding.

If you are undergoing treatment for cancer or going for an operation, including minor operations and dental work, always inform your doctor or dentist that you are being treated with Clodronic Acid injection.

This medicine may cause your jaw bones to weaken. You may experience dental problems such as jaw swelling and pain, loose or shaky teeth. It is important to maintain good oral hygiene while being treated with this medicine. Your doctor may recommend that you have a dental check-up before starting you on this medicine. Inform your doctor and dentist if you:

- develop a tooth infection
- develop pain, numbness or discomfort in your teeth or gums
- have a tooth extraction

You will need to have regular blood and urine tests to check your calcium levels and kidney function. Your doctor will advise you about how often you need to have these tests.
What side effects could I experience?
Clodronic Acid injection may cause any of the following side effects: pain, irritation and redness at the injection site, nausea, vomiting, stomach pain, diarrhoea and loss of appetite.

Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.

Can I use this with other medicines?
Do not use Clodronic Acid injection if you are taking other similar medicines such as pamidronate, alendronate, risedronate or zoledronate.

Inform your doctor if you are taking any of the following any of these medicines:

- NSAIDs (medicine for pain and inflammation) e.g. ibuprofen, aspirin
- antibiotics e.g. amikacin, gentamicin
- medicine for cancer especially estramustine

This list does not include all medicines that may interact with Clodronic Acid injection.

Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicine, supplements and medicines that you buy without a prescription.
What special dietary instructions should I follow?
Avoid alcohol.
How should I store this medicine?
Store in a cool, dry place below 25 °C. Keep away from the reach of children.

Store the injection in its original carton and protect from light. Light may cause the medication to lose some of its effectiveness. If the injection changes colour, do not use it.

Once diluted, the injection must be used within 12 hours. Throw away any diluted solution that is not used within 12 hours.

Medicines must not be used past the expiry date.
This information is independently developed by MIMS based on Clodronic Acid - Intravenous and is provided for your reference only. It is not a replacement for and should only be used in conjunction with full consultation with a licensed healthcare professional, the information provided by your pharmacist and/or the manufacturer of the medication. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, we shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 MIMS. All rights reserved. Powered by
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