Clotrimazole GPO

Clotrimazole GPO

clotrimazole

Manufacturer:

GPO

Distributor:

GPO
Full Prescribing Info
Contents
Clotrimazole.
Description
Each 100 g contains clotrimazole 1.0 g.
Action
Pharmacology: Mechanism of Action: Clotrimazole, an imidazole derivative, is a synthetic azole antifungal agent. It exerts antifungal activity by altering cell membrane permeability, apparently by binding with phospholipids in the fungal cell membrane. As a result, the cell membrane is unable to function as a selective barrier, and potassium and other cellular constituents are lost.
Pharmacokinetics: Only very small amounts of clotrimazole appear to be absorbed systemically following topical application to the skin. Following application to the skin, highest concentrations of clotrimazole are presented in the stratum corneum; lower drug concentration occur in the stratum spinosum and the papillary and reticular dermis.
Indications/Uses
Treatment of candidiasis caused by Candida albicans.
Treatment of tinea corporis, tinea cruris, and tinea pedis caused by Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, or Microsporum canis.
Treatment of pityriasis (tinea) versicolor caused by Malassezzia furfur (Pityrosporum orbiculare or P. ovale).
Dosage/Direction for Use
Clotrimazole cream should be applied sparingly and rubbed gently into the cleansed, affected area and surrounding skin twice daily (in the morning and evening). Clinical improvement usually occur within 1 week.
For Tinea corporis: should be treated for 4 weeks.
Tinea cruris: should be treated for 2 weeks.
Tinea pedis: should be treated for 4 weeks.
Tinea versicolor: should be treated for 4 weeks.
Notes: Systemic ketoconazole (e.g., itraconazole, fluconazole and terbinafine) is indicated, in combination with topical imidazole, in the treatment of tinea capitis (ringworm of the scalp).
An oral antifungal (e.g., itraconazole, fluconazole and terbinafine) usually is necessary for the treatment of onychomycosis.
Contraindications
Clotrimazole is contraindicated in patients who are hypersensitive to the drug or any ingredient in the formulation.
Special Precautions
Avoiding contact with the eyes.
Use in Pregnancy & Lactation: Clotrimazole should be used during the first trimester of pregnancy only if clearly indicated.
Since it is not known whether clotrimazole is distributed in milk, the drug should be used with caution in nursing women.
Use in Children: It should not be used in children younger than 2 years of age unless otherwise instructed by a physician.
Use In Pregnancy & Lactation
Clotrimazole should be used during the first trimester of pregnancy only if clearly indicated.
Since it is not known whether clotrimazole is distributed in milk, the drug should be used with caution in nursing women.
Side Effects
Burning, blistering, swelling, itching, urticaria, and irritating have occurred.
Storage
Store below 25°C.
ATC Classification
D01AC01 - clotrimazole ; Belongs to the class of imidazole and triazole derivatives. Used in the topical treatment of fungal infection.
Presentation/Packing
Cream 1% x 15 g, 500 g.
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