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CoAprovel

CoAprovel

irbesartan + hydrochlorothiazide

Manufacturer:

Sanofi-Aventis

Distributor:

DKSH
Concise Prescribing Info
Contents
Per 150/12.5 tab Irbesartan 150 mg, hydrochlorothiazide 12.5 mg. Per 300/12.5 tab Irbesartan 300 mg, hydrochlorothiazide 12.5 mg. Per 300/25 tab Irbesartan 300 mg, hydrochlorothiazide 25 mg
Indications/Uses
Essential HTN. Initial treatment when HTN is severe & rapid control of BP is of primary clinical importance.
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Dosage/Direction for Use
1 tab daily. Max daily dose: 300 mg irbesartan & 25 mg hydrochlorothiazide.
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Overdosage
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Administration
May be taken with or without food.
Contraindications
Concomitant use w/ aliskiren-containing drugs in patients w/ diabetes or moderate to severe renal impairment; concomitant use w/ ACE inhibitors in patients w/ diabetic nephropathy; severe renal or hepatic impairment; refractory hypokalemia, hypercalcemia; biliary cirrhosis or cholestasis; 2nd & 3rd trimester of pregnancy; lactation.
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Special Precautions
Increased risk of hypotension, hyperkalemia, & changes in renal function in concomitant use w/ ACE inhibitors or aliskiren. Hypotension, vol-depleted patients, renal artery stenosis, renovascular HTN, renal & hepatic impairment, kidney transplantation, aortic & mitral valve stenosis, obstructive hypertrophic cardiomyopathy, primary aldosteronism, metabolic & endocrine effects, electrolyte imbalance, lithium, antidoping test. May impair ability to drive or operate machinery.
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Adverse Reactions
Dizziness, nausea/vomiting, abnormal urination, fatigue.
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Drug Interactions
Other antihypertensive agents, K supplements & K-sparing diuretics, digitalis glycosides, antiarrhythmics, lithium, COX-2 inhibitors. Hydrochlorothiazide may interact w/ alcohol, antidiabetics, cholestyramine & colestipol resins, corticosteroids, digitalis glycosides, NSAIDs, pressor amines, skeletal muscle relaxants, antigout drugs, Ca salts.
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Storage
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Description
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Action
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ATC Classification
C09DA04 - irbesartan and diuretics ; Belongs to the class of angiotensin II receptor blockers (ARBs) in combination with diuretics. Used in the treatment of cardiovascular disease.
Presentation/Packing
Form
CoAprovel 300/12.5 tab
Packing/Price
28's
Form
CoAprovel 150/12.5 tab
Packing/Price
28's
Form
CoAprovel 300/25 tab
Packing/Price
28's
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