Treatment of infections due to sensitive strains of certain gram-negative bacilli which are resistant to other antibacterial or in patients allergic to other antibacterial (e.g., Acinetobacter spp., Citrobacter spp., Escherichia coli, Enterobacter spp., Haemophilus influenzae, Klebsiella pneumoniae, Pseudomonas aeruginosa, Salmonella spp., Shigella spp. and some strains of Bordetella spp. and Vibrio spp.).
Aerosolized colistin has been shown to be beneficial in the treatment of sensitive Pseudomonas infections in patients with cystic fibrosis by oral inhalation via nebulization.