Coversyl Arginine

Coversyl Arginine

perindopril

Manufacturer:

Servier

Distributor:

DKSH
Concise Prescribing Info
Contents
Perindopril arginine
Indications/Uses
Arterial HTN, CHF, combination w/ indapamide to reduce the risk of stroke recurrence in patients w/ history of stroke or TIA, & reduction of risk of CV events in patients w/ stable CAD, on top of other preventive medications.
Dosage/Direction for Use
Adult Arterial HTN 5 mg/day in the morning. May be increased to 10 mg/day in a single dose after 1 mth of treatment. Elderly Initially 2.5 mg/day. May be increased to 5 mg/day after 1 mth of treatment. CHF Initially 2.5 mg/day in the morning up to 5 mg/day. Prevention of stroke recurrence in patients w/ a history of cerebrovascular disease 2.5 mg/day for 2 wk, then increase to 5 mg/day for a further 2 wk before introducing indapamide. Reduction of risk of CV event in patients w/ stable coronary artery disease 5 mg once daily for 2 wk up to 10 mg once daily. Elderly 2.5 mg once daily for 1 wk then 5 mg once daily the next wk before increasing to 10 mg once daily.
Administration
Should be taken on an empty stomach.
Contraindications
Hypersensitivity including angioneurotic edema-type reactions. 2nd/3rd trimester pregnancy. 1st trimester pregnancy or during lactation. DM or renal problems treated w/ a BP lowering drug containing aliskiren. 
Special Precautions
Discontinue treatment if hypersensitivity/angioedema/intestinal angioedema & monitor until complete resolution of symptoms. Concomitant mTOR inhibitors (eg, sirolimus, everolimus, temsirolimus) therapy may increase risk of angioedema. Withhold treatment prior to exam for anaphylactoid reactions during low-density lipoproteins (LDL) apheresis. Patients w/ collagen vascular disease, immunosuppressant therapy, treated w/ allopurinol or procainamide. Increased risk of hypotension, hyperkalaemia in concomitant use of ACE inhibitors, angiotensin II receptor blockers or aliskiren. Concomitant use of ACE inhibitors & angiotensin II receptor blockers in patients w/ diabetic nephropathy. Aortic valve stenosis/hypertrophic cardiomyopathy. Stable CAD. Monitor K & creatinine. Discontinue treatment if jaundice or marked elevations of hepatic enzymes occurs; 1 day prior to surgery. Black people. Frequently monitor blood K if renal insufficiency, renal function worsening, DM, dehydration, acute cardiac decompensation, concomitant use of K-sparing diuretics & K salts. Galactose intolerance/glucose-galactose malabsorption/Lapp-lactase deficiency. Not recommended during 1st trimester of pregnancy & lactation. 2nd & 3rd trimester of pregnancy is contraindicated. Low BP may occur in some patients while driving or using machinery.
Adverse Reactions
Headache, dizziness, vertigo, pins & needles, visual disturbances, tinnitus, lightheadedness due to low BP, cough, shortness of breath, GI disturbances, allergic reactions, muscle cramps, feeling of weakness, paraesthesia, hypotension, dyspnoea, abdominal pain, constipation, diarrhoea, dysgeusia, dyspepsia, nausea, vomiting, pruritus, rash, asthenia, hypoglycaemia, hyperkalaemia, hyponatraemia, mood disturbances, sleep disorder, somnolence, syncope, palpitations, tachycardia, vasculitis, bronchospasm, dry mouth, urticaria, angioedema of face, extremities, lips, mucous membranes, tongue, glottis &/or larynx, photosensitivity reactions, pemphigoid, hyperhydrosis, arthralgia, myalgia, renal insufficiency, erectile dysfunction, chest pain, malaise, peripheral oedema, pyrexia, blood urea increased, increased blood creatinine, fall, psoriasis aggravation, increased blood bilirubin & hepatic enzyme, agranulocytosis or pancytopenia, decreased Hb & haematocrit, confusion, angina pectoris, arrhythmia, MI, stroke, eosinophilic pneumonia, rhinitis, pancreatitis, hepatitis, erythema multiform, acute renal failure.
Drug Interactions
Contraindicated: Aliskiren (in diabetic or impaired renal patients) Not recommended: Aliskiren, angiotensin-receptor blockers, estramustine, racecadotril, mTOR inhibitors (eg, sirolimus, everolimus, temsirolimus), K-sparing drugs (triamterene, amiloride), K supplements or K salts, lithium. Antidiabetic agents (insulins, oral hypoglycaemic agents), baclofen, non-K-sparing diuretics, K-sparing diuretics (eplerenone, spironolactone), NSAIDs including aspirin (≥3 g/day). Antihypertensives, vasodilators, gliptines (linagliptine, saxagliptine, sitagliptine, vildagliptine), TCAs, antipsychotics, anesth, sympathomimetics, gold. Aliskiren, ACE inhibitors, angiotensin-II receptors antagonists, heparins, immunosuppressants eg, ciclosporin or tacrolimus, trimethoprim. 
ATC Classification
C09AA04 - perindopril ; Belongs to the class of ACE inhibitors. Used in the treatment of cardiovascular disease.
Presentation/Packing
Form
Coversyl Arginine FC tab 10 mg
Packing/Price
30's
Form
Coversyl Arginine FC tab 5 mg
Packing/Price
30's
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