Crixan Mechanism of Action





Full Prescribing Info
Pharmacology: Pharmacodynamics: Mechanism of Action: Clarithromycin exerts its antibacterial action by binding to the 50S ribosomal subunit of susceptible bacteria and suppresses protein synthesis. It is active against a wide variety of aerobic and anaerobic gram-positive and gram-negative organisms. The 14-hydroxy metabolites of clarithromycin also has antimicrobial activity.
Microbiology: Antibacterial Spectrum: Clarithromycin is usually active against the following organisms in vitro: Gram-Positive Bacteria: Staphylococcus aureus (methicillin susceptible), Streptococcus pyogenes (group A β-haemolytic streptococci), α-haemolytic streptococci (viridans group), Streptococcus (Diplococcus) pneumoniae, Streptococcus agalactiae, Listeria monocytogenes.
Gram-Negative Bacteria: Haemophilus influenzae, Haemophilus parainfluenzae, Moraxella (Branhamella) catarrhalis, Neisseria gonorrhoeae, Legionella pneumophila, Bordetella pertussis, Helicobacter pylori.
Mycoplasma: Mycoplasma pneumoniae.
Other Organisms: Chlamydia trachomatis, Mycobacterium avium, Mycobacterium leprae.
Anaerobes: Macrolides-susceptible Bacteroides fragilis, Clostridium perfringens, Peptococcus and Peptostreptococcus spp, Propionibacterium acnes.
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