General: Clarithromycin is principally excreted by the liver and kidney. Caution should be exercised in administering clarithromycin to patients with impaired hepatic and renal function. Prolonged or repeated use of clarithromycin may result in an overgrowth of nonsusceptible bacteria or fungi. If superinfection occurs, clarithromycin should be discontinued and appropriate therapy instituted.
Use in pregnancy & lactation: The safety of clarithromycin during pregnancy and breastfeeding of infants has not been established. Clarithromycin should, thus, not be used during pregnancy or lactation unless the benefit outweighs the risk. Clarithromycin is secreted in the breast milk.