Diamicron MR 60 mg

Diamicron MR 60 mg Dosage/Direction for Use





Full Prescribing Info
Dosage/Direction for Use
Diamicron: Standard Dosage: 2 tabs/day in 2 daily doses. As with all hypoglycaemic agents, the dosage must be adapted to suit each individual case. If the patient feels that the effect of Diamicron is too strong or too weak, consult the doctor or pharmacist.
Diamicron MR: 30 mg Tablet: Adults: Usual Daily Dose: 1-4 tabs/day as a single dose. It is recommended that the drug be taken at breakfast.
60 mg Scored Tablet: Adults: The daily dose of Diamicron MR 60 mg scored tablet may vary from ½-2 tabs/day ie, from 30-120 mg taken orally in a single intake at breakfast time.
As with any hypoglycaemic agent, the dose should be adjusted according to the individual patient's metabolic response (blood glucose, HbA1c).
Initial Dose: The recommended starting dose is 30 mg daily (½ tab Diamicron MR 60 mg scored tablet). If blood glucose is effectively controlled, this dose may be used for maintenance treatment. If blood glucose is not adequately controlled, the dose may be increased to 60, 90 or 120 mg daily, in successive steps. The interval between each dose increment should be at least 1 month except in patients whose blood glucose has not reduced after 2 weeks of treatment. In such cases, the dose may be increased at the end of the 2nd week of treatment.
The maximum recommended daily dose is 120 mg.
One (1) Diamicron MR 60 mg modified-release scored tablet is equivalent to 2 Diamicron MR 30 mg modified-release tablets. The breakability of the Diamicron MR 60 mg modified-release scored tablet enables flexibility of dosing to be achieved.
Switching from Diamicron 80 mg Tablets to Diamicron MR 60 mg Modified-Release Scored Tablets: 1 tab Diamicron 80 mg is comparable to 30 mg of the modified-release formulation (ie, ½ tab Diamicron MR 60 mg scored tablet). Consequently, the switch can be performed with careful blood monitoring.
Switching from Another Oral Antidiabetic Agent to Diamicron MR 60 mg Score Tablet: Diamicron MR 60 mg Scored Tablet can be used to replace other oral antidiabetic agents. The dosage and the half-life of the previous antidiabetic agent should be taken into account when switching to Diamicron MR 60 mg scored tablet.
A transitional period is not generally necessary. A starting dose of 30 mg should be used and this should be adjusted to suit the patient's blood glucose response, as described previously.
When switching from a hypoglycaemic sulfonylurea with a prolonged half-life, a treatment-free period of a few days may be necessary to avoid an additive effect of the 2 products, which might cause hypoglycaemia. The procedure described for initiating treatment should also be used when switching to treatment with Diamicron MR 60 mg scored tablet ie, a starting dose of 30 mg/day, followed by a stepwise increase in dose, depending on the metabolic response.
Combination Treatment with Other Antidiabetic Agents: Diamicron MR 60 mg scored tablet can be given in combination with biguanides, α-glucosidase inhibitors or insulin.
In patients not adequately controlled with Diamicron MR 60 mg scored tablet, concomitant insulin therapy can be initiated under close medical supervision.
In the elderly (>65 years), Diamicron MR 60 mg scored tablet should be prescribed using the same dosing regimen recommended for patients <65 years.
In patients with mild to moderate renal insufficiency (GFR=60-89 and 30-59 mL/min/1.73 m2, respectively), the same dosing regimen can be used as in patients with normal renal function with careful patient monitoring. These data have been confirmed in clinical trials, with treatment up to 10 months.
Patients at Risk of Hypoglycaemia: Undernourished or malnourished; severe or poorly compensated endocrine disorders (hypopituitarism, hypothyroidism, adrenocorticotrophic insufficiency); withdrawal of prolonged and/or high-dose corticosteroid therapy; severe vascular disease (severe coronary heart disease, severe carotid impairment, diffuse vascular disease).
It is recommended that the minimum daily starting dose of 30 mg is used.
There are no data and clinical studies available in children.
Administration: The tablets must be taken whole with half a glass of water just before breakfast.
It is recommended to swallow the dose of Diamicron MR without crushing or chewing.
It is preferable to take Diamicron MR before breakfast in order to avoid or to minimise the possible onset of digestive disorders.
Frequency of Administration: The once-daily administration of Diamicron MR must always be followed by a meal.
If a dose is forgotten, take 1 tab with the next meal. Do not take a double dose to compensate the single dose that has been forgotten. There must be no increase in the dose taken the next day.
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