Diazepam GPO

Diazepam GPO

diazepam

Manufacturer:

GPO

Distributor:

GPO
Concise Prescribing Info
Contents
Diazepam
Indications/Uses
Tab: Relief of anxiety & muscle relaxation. IV: Management of anxiety, mental tension, restlessness, agitation & acute alcohol w/drawal symptoms eg, agitation, tremor, & hallucinations. Adjunctive therapy in status epilepticus, severe recurrent convulsive seizures, & for relief of skeletal muscle spasm. Preop medication.
Dosage/Direction for Use
Tab Adult Anxiety 2-10 mg bid-qid. Muscle relaxant 2-10 mg tid-qid. IM/IV Adult Antianxiety 5-10 mg. Repeat dose in 3-4 hr, if necessary. Skeletal muscle relaxant adjunct Initially 5-10 mg. Repeat dose in 3-4 hr, if necessary. IV Anticonvulsant Adult Initially 5-10 mg. Dose may be repeated at 10-15 min interval up until max 30 mg. Repeat dose in 2-4 hr.
Administration
May be taken with or without food.
Contraindications
Concomitant use w/ CNS depressants or products containing alcohol. Tab: Hypersensitivity, acute closed-angle glaucoma, psychoses. Inj: Tolerance, psychologic & physical dependence may occur in prolonged use. Patients w/ hepatic & renal disease, glaucoma, myasthenia gravis, porphyria, chronic pulmonary insufficiency. Avoid driving, using of machines or tasks requiring alertness. Concomitant use w/ TCAs, antidepressants, cimetidine & disulfiram. Pregnancy & lactation.
Special Precautions
Tab: Do not use in patients w/ history of benzodiazepine allergy. Avoid abrupt w/drawal & prolonged use. Liver or renal impairment, closed-angle glaucoma, myasthenia gravis, porphyria, resp disorders, sleep apnea, chronic alcoholism, psychiatric disorders including psychosis, depression, drug abuse. Concomitant administration w/ inducers/inhibitors of liver enzyme metabolizing benzodiazepines. May cause abnormal blood profile. Hypoalbuminemic patients. Discontinue if insomnia, hallucination, abnormal behavior, ataxia or fever occurs. Driving or operating machine, or dealing w/ hazardous activities is not recommended during therapy. Pregnancy & lactation. Paradoxical effects in childn & elderly. Inj: Patients w/ acute alcohol intoxication w/ depressed vital signs, severe COPD, acute angle-closure glaucoma, hypersensitivity to benzodiazepines. Pregnancy (1st trimester).
Adverse Reactions
Dizziness, vertigo. Tab: CNS depression including drowsiness, uncooperative muscle improvement, loss of movement control, confusion, dizziness, palpitation, tachycardia, temporary memory loss, GI irritation, skin reactions. Inj: Drowsiness, ataxia, fatigue, & syncope. Apnea, hypotension, bradycardia or cardiac arrest. Phlebitis, blood vessel clot.
Drug Interactions
Tab: Increase CNS effects & risk of apnea w/ CNS depressants & alcohol. Decreased clearance w/ CYP2C19 inhibitors including cimetidine, quinidine, tranylcypromine. Increased clearance w/ CYP2C19 inducers including rifampicin. Decreased absorption w/ ranitidine.
MIMS Class
ATC Classification
N05BA01 - diazepam ; Belongs to the class of benzodiazepine derivatives anxiolytics. Used in the management of anxiety, agitation or tension.
Presentation/Packing
Form
Diazepam GPO tab 5 mg
Packing/Price
1000's
Form
Diazepam GPO tab 10 mg
Packing/Price
1000's
Form
Diazepam GPO inj 10 mg/2 mL
Packing/Price
50 × 1's
Form
Diazepam GPO tab 2 mg
Packing/Price
500's
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