Doracept

Doracept

donepezil

Manufacturer:

GPO

Distributor:

GPO
Concise Prescribing Info
Contents
Donepezil HCl
Indications/Uses
Mild, moderately severe & severe dementia of Alzheimer's type, vascular dementia (dementia associated w/ cerebrovascular disease), dementia w/ Lewy's bodies (DLB).
Dosage/Direction for Use
Mild to moderate Alzheimer's disease 5 or 10 mg once daily. Moderate to severe Alzheimer's disease 10 or 23 mg once daily. Vascular dementia Min effective dose: 5 mg once daily, may be treated up to 10 mg daily after 4 wk. Dementia w/ Lewy's body 3 mg once daily for 2 wk then increase to 5 mg once daily.
Administration
May be taken with or without food: Place tab on the tongue & allow to disintegrate before swallowing w/ water.
Contraindications
Hypersensitivity to donepezil or piperidine derivatives.
Special Precautions
Bradycardia &/or heart block w/ or w/o history of cardiac disease; syncopal episodes. Sick sinus syndrome or other supraventricular cardiac conduction abnormalities, w/ seizures, COPD or asthma. Patients at risk of ulcer disease (eg, previous history of NSAID use) or w/ bladder outlet obstruction. Concomitant use w/ depolarizing neuromuscular-blocking agents ie, succinylcholine. Pregnancy & lactation. Childn. Risk of antipsychotic-related extrapyramidal symptoms may be increased.
Adverse Reactions
Insomnia; nausea, diarrhea; accident, infection.
Drug Interactions
Synergistic effect may occur w/ succinylcholine or cholinergic agonists (bethanechol). May enhance bradycardic effects of β-blockers. Effects may be inhibited by anti-cholinergic agents (benztropine). May diminish neuromuscular-blocking effects of nondepolarizing blockers. Decreased levels w/ St. John's wort. Adverse effects/toxicity may be increased w/ Ginkgo biloba.
MIMS Class
Neurodegenerative Disease Drugs
ATC Classification
N06DA02 - donepezil ; Belongs to the class of anticholinesterases. Used in the management of dementia.
Presentation/Packing
Form
Doracept orally disintegrating tab 10 mg
Packing/Price
3 × 10's
Form
Doracept orally disintegrating tab 5 mg
Packing/Price
3 × 10's
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Sign up for free
Already a member? Sign in