Special Precautions for disposal and other handling: Recommendations for safe handling: Dacarbazine is an antineoplatic agent and should be handled according to standard procedures for cytostatics that have mutagenic, carcinogenic and teratogenic effects. Before commencing local cytotoxic guideline should be referred to.
Dacarbazine should only opened by trained staff and as with all cytotoxic agent; precautions should be taken to avoid exposing staff. Handling of cytotoxic medicinal products should be generally avoided during pregnancy. Preparation of solution for administration should be carried out in a designated handling area and working over a washable tray or disposable plastic-backed absorbent paper.
Suitable eye protection, disposable gloves, face mask and disposable apron should be worn.
Syringes and infusion sets should be assembled carefully to avoid leakage (use of Luer lock fittings is recommended).
On completion, any exposed surface should be thoroughly cleaned and hands and face washed.
In the event of spillage, operators should put on gloves, face masks, eye-protection and disposable apron and mop up the spilled material with a contaminated material transferred to a cytotoxic spillage bag or bin or sealed for incineration.