DTI for Injection

DTI for Injection Use In Pregnancy & Lactation



Korea United Pharm [KR]


Full Prescribing Info
Use In Pregnancy & Lactation
Pregnancy: There are no adequate and controlled studies to date in human, dacarbazine has been shown to be teratogenic in rats when given at dosage 20 times the usual human dosage. Dacarbazine should be used during pregnancy only if the potential benefit justifies the possible risks to the fetus.
The effect of dacarbazine on fertility in humans is not known. Reproduction studies in male rats using dacarbazine dosage 10 times the usual human dosage have not revealed evidence of impaired fertility; however, in female rats receiving dacarbazine, fetal resorptions occurred more frequently than in rats receiving placebo.
Lactation: It is not known whether dacarbazine is distributed into milk. Because of the carcinogenic potential of dacarbazine in nursing infants, a decision should be made whether to discontinue nursing or the drug, taking into account the importance of the drug to the woman.
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