Regularly evaluate men for prostate cancer while receiving treatment. Patients receiving treatment should have a new prostate-specific antigen (PSA) baseline established after 6 mth of treatment; monitor PSA values regularly thereafter. Perform digital rectal exam prior to initiating therapy & periodically thereafter. Higher incidence of cardiac failure (primarily cardiac failure & congestive cardiac failure) in concomitant use w/ an α-blocker, primarily tamsulosin. Mild to moderate hepatic impairment. Women, childn & adolescents should avoid contact w/ leaking cap. Avoid exposure of pregnant or potentially pregnant female partner to semen.