Adult600 mg once daily. Adolescents & childn (3-17 yr) ≥40 kg 600 mg, 32.5 to <40 kg 400 mg, 25 to <32.5 kg350 mg, 20 to <25 kg 300 mg, 15 to <20 kg 250 mg, 13 to <15 kg 200 mg. Maintenance dose: In combination w/ voriconazole: Voriconazole dose may be increased to 400 mg every 12 hr & reduce efavirenz dose to 300 mg once daily. In combination w/ rifampicin: Increase efavirenz dose to 800 mg/day.
Mild to moderate liver disease & severe renal failure. History of psychiatric disorders & seizures. Periodic monitoring of plasma levels in patients receiving concomitant anticonvulsant drugs. Immunodeficiency. Lipodystrophy in HIV patients. Osteonecrosis in patients w/ advanced HIV disease &/or long-term exposure to combination antiretroviral therapy. Rare hereditary disorders of galactosemia or glucose/galactose malabsorption syndrome. May impair ability to drive or operate machinery. Childn <3 yr w/ <13 kg body wt. Pregnancy.