Efamat

Efamat

efavirenz

Manufacturer:

Mylan

Distributor:

Atlanta Medicare
Concise Prescribing Info
Contents
Efavirenz
Indications/Uses
Treatment of HIV-1 infected adults, adolescents & childn ≥3 yr. 
Dosage/Direction for Use
Adult 600 mg once daily. Adolescents & childn (3-17 yr) ≥40 kg 600 mg, 32.5 to <40 kg 400 mg, 25 to <32.5 kg 350 mg, 20 to <25 kg 300 mg, 15 to <20 kg 250 mg, 13 to <15 kg 200 mg. Maintenance dose: In combination w/ voriconazole: Voriconazole dose may be increased to 400 mg every 12 hr & reduce efavirenz dose to 300 mg once daily. In combination w/ rifampicin: Increase efavirenz dose to 800 mg/day.
Administration
Should be taken on an empty stomach: Take preferably at bedtime.
Contraindications
Hypersensitivity. Severe hepatic impairment (Child-Pugh grade C). Lactation.
Special Precautions
Mild to moderate liver disease & severe renal failure. History of psychiatric disorders & seizures. Periodic monitoring of plasma levels in patients receiving concomitant anticonvulsant drugs. Immunodeficiency. Lipodystrophy in HIV patients. Osteonecrosis in patients w/ advanced HIV disease &/or long-term exposure to combination antiretroviral therapy. Rare hereditary disorders of galactosemia or glucose/galactose malabsorption syndrome. May impair ability to drive or operate machinery. Childn <3 yr w/ <13 kg body wt. Pregnancy.
Adverse Reactions
Rash. Anxiety, depression; abnormal dreams, disturbance in attention, dizziness, headache, insomia, somnolence; abdominal pain, diarrhoea, nausea, vomiting, pruritus, fatigue.
Drug Interactions
Altered exposure w/ grapefruit juice. Inhibition of metabolism of terfenadine, astemizole, cisapride, midazolam, triamzolam, pimozide, bepridil, ergotamine, dihydroergotamine, ergonovine, methylergonovine. Reduced plasma levels w/ St. John's wort.
MIMS Class
ATC Classification
J05AG03 - efavirenz ; Belongs to the class of non-nucleoside reverse transcriptase inhibitors. Used in the systemic treatment of viral infections.
Presentation/Packing
Form
Efamat FC tab 200 mg
Packing/Price
30's
Form
Efamat FC tab 600 mg
Packing/Price
30's
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