Emthexate

Emthexate

methotrexate

Manufacturer:

Pharmachemie/Teva

Distributor:

Pacific Healthcare
Concise Prescribing Info
Contents
Methotrexate
Indications/Uses
Breast carcinoma, choriocarcinoma, chorioadenoma destruens & hydatidiform mole, lymphocytic & meningeal leukaemia, lymphosarcoma, mycosis fungoides, psoriasis.
Dosage/Direction for Use
Trophoblastic tumours 15-30 mg IM daily for 5 days. Repeat after 1 or more wk when toxicity disappears. Usually administer for 3-5 courses. Acute lymphoblastic leukemia 3.3 mg/m2 orally w/ prednisolone for 4-6 wk. Maintenance: 20-30 mg/m2 orally or IM twice wkly or 2.5 mg/kg IV every 14 days. Meningeal leukemia 0.2-0.5 mg/kg at 2-5 day intervals intrathecally when CSF cell counts are normal, then give 1 more dose or 12 mg/m2 once wkly for 2 wk, then once a mth. Mycosis fungoides 2.5-10 mg/day orally or 50 mg IM once wkly or 25 mg twice wkly. Psoriasis Divided oral dosage: 2.5 mg 12 hrly for 3 doses/wk or 8 hrly for 4 doses/wk. Max wkly dose: 30 mg. Daily oral dosage: 2.5 mg/day for 5 days. Rest for >2 days. Max 6.25 mg/day. Wkly dosage: 10-25 mg orally, IM or IV once wkly. Max: 50 mg/wk.
Administration
Should be taken on an empty stomach: May be taken w/ meals to reduce GI discomfort. Avoid taking w/ milk-rich products.
Contraindications
Pregnancy & lactation. Psoriatic patient in a poor state of nutrition, serious renal or liver disorders, bone marrow hyperplasia, leukopenia, thrombocytopenia or anemia.
Special Precautions
Perform hematological studies, urine analysis, renal function test & chest radiographs.
Adverse Reactions
Hepatotoxicity, GI, dermatological, liver & GUT toxicity.
Drug Interactions
Effects enhanced by salicylates, sulfonamides, diphenylhydantoin, tetracyclines, chloramphenicol, aminobenzoic acid. Folic acid prep decreases its effectiveness.
ATC Classification
L01BA01 - methotrexate ; Belongs to the class of antimetabolites, folic acid analogues. Used in the treatment of cancer.
L04AX03 - methotrexate ; Belongs to the class of other immunosuppressants.
Presentation/Packing
Form
Emthexate tab 2.5 mg
Packing/Price
(blister) 10 × 10's
Form
Emthexate inj 50 mg/2 mL
Packing/Price
1's
Form
Emthexate inj 1000 mg/10 mL
Packing/Price
1's
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