Discontinue use if MI, cerebrovascular disorders, arterial or venous thromboembolism, thrombophlebitis or retinal thrombosis are suspected, or if transient ischemic events, appearance of sudden severe headaches, or vision impairments related to papillary edema or retinal hemorrhage occurs. Closely observe patients w/ history of depression, epilepsy, migraine, asthma, cardiac or renal dysfunction & diabetics. Patients who are >35 yr, smokers, & those w/ risk factors for atherosclerosis. May cause increased anxiety, moodiness & increased sensibility to seizures w/ abrupt discontinuation. Mild to moderate hepatic dysfunction. May affect ability to drive or operate machinery. Pregnancy & lactation.