Concomitant use w/ ACE inhibitors, aliskiren, sildenafil, inhibitors of OATP1B1, OATP1B3, OAT3 (eg, rifampin, cyclosporine) or multidrug resistance-associated protein 2 (eg, ritonavir). Not recommended w/ ARB-containing product. Increased Cmax
of atorvastatin. Increased serum K & creatinine w/ K-sparing diuretics (eg, triamterene, amiloride), mineralocorticoid antagonists (eg, spironolactone, eplerenone), K supplements or K-containing salt substitutes. Increased risk of worsening of renal function w/ NSAIDs including selective COX-2 inhibitors. Reversible increased serum lithium conc & toxicity.