Hypersensitivity to the active substance, sacubitril, valsartan, or to any of the excipients.
Concomitant use with ACE inhibitors (see PRECAUTIONS, DOSAGE & ADMINISTRATION and INTERACTIONS). Entresto must not be administered until 36 hours after discontinuing ACE inhibitor therapy.
Known history of angioedema related to previous ACE inhibitor or ARB therapy.
Concomitant use with aliskiren in patients with Type 2 diabetes (see PRECAUTIONS and INTERACTIONS).
Pregnancy (see USE IN PREGNANCY & LACTATION).